Laparoscopic Surgery
Conditions
Keywords
laparoscopic surgery, deep neuromuscular blockade
Brief summary
Find out the deciding factor(total body weight, corrected body weight, ideal body weight, fat-free mass, body mass index, skeletal muscle mass, body fat) of neuromuscular blocker dose for deep neuromuscular blockade.
Detailed description
Before the surgery, total body weight, corrected body weight, ideal body weight, fat-free mass, body mass index were measured by height and weight and skeletal muscle mass and body fat were measured by Bioelectrical impedance analysis (InbodyH20N). Find the highest correlation between the 8 factors (total body weight, corrected body weight, ideal body weight, fat-free mass, body mass index, skeletal muscle mass, body fat) and the amount of rocuronium administered to deep neuromuscular blockade.
Interventions
Train of Four=0/4, Post tetanic count 1-2
Sponsors
Seoul National University Bundang Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
20 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* patients aged 20-80 and American Society of Anesthesiology Physical Grade (ASA) I-II, who undergo laparoscopic surgery for at least 2 hours under general anesthesia
Exclusion criteria
* kidney disease (GFR\<60) * allergy to study drugs * decline participation * side effect of propofol and remifentanil * when anesthesia does not maintain the level of alertness (BIS) below 60 even when the anesthetic dose is increased, or when hemodynamic instability such as bradycardia and hypotension appears
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| the highest correlation coefficient | preoperative 1 days to postoperative 1 days | the relationship of rocuronium for deep neuromuscular blockade and 8 factors (corrected body weight, ideal body weight, lean body weight, fat-free mass, body mass index, skeletal muscle mass, body fat) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| onset time of rocuronium | preoperative 1 days to postoperative 1 days | time from injection of rocuronium 0.6 mg/kg(TBW) to TOF ratio is less than 0.05 |
| Time to deep neuromuscular blockade | preoperative 1 days to postoperative 1 days | time from injection of rocuronium 0.6 mg/kg(TBW) to PTC 1 |
| Recovery time | preoperative 1 days to postoperative 1 days | time from sugammadex injection to TOF ratio \> 0.9 |
Contacts
Primary ContactJiwon Han, Dr
Backup ContactAh-young Oh, Dr
Outcome results
None listed