Juvenile Idiopathic Arthritis, Persistent Knee Arthritis, no Intra-articular Injection in the Last 3 Months, no Other Cause for Chronic Kneearthritis
Conditions
Keywords
Juvenile rheumatoid arthritis, knee joint, Nerve block
Brief summary
N=104 juvenile idiopathic arthritis patients diagnosed after ILAR criteria with unilateral persistent knee arthritis. They will be randomly assigned into two groups; group 1 will receive genicular nerve block, group 2 intra-articular triamcinolone. Both groups will be examined by SOLAR ultrasound scoring system, Visual analogue scale and Lysholm score at 0, 2 and 12 weeks. A semi-quantitative score will be used to assess tenderness and swelling at the same intervals.
Interventions
nerve block of the genicular nerve at 3 points around the inflamed knee using ultrasound.
Triamcinilone injection into the knee joint under ultrasound guidance.
Sponsors
Sohag University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
No minimum to 16 Years
Healthy volunteers
No
Inclusion criteria
* juvenile idiopathic arthritis with persistent knee arthritis * age below 16
Exclusion criteria
* severe knee osteoarthritis * peripheral neuropathy, * psoriatic arthritis, * those under anticoagulant therapy, skin infection, * prior knee injection in the last 3 months3 * those who have an allergy to Bupivacaine
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in SOLAR score over time | Baseline, 2 weeks and 12 weeks | score to assess ultrasound parameters of the knee including power doppler and grey scale measures |
| Change in visual analogue scale over time | Baseline, 2 weeks and 12 weeks | a graded score for pain evaluation filled by the patient graded from 0 to 10 |
| Change in Lysholm score over time | Baseline, 2 weeks and 12 weeks | a score to assess knee function. This questionnaire has 8 domains. A score between 95 and 100 means excellent functional performance, good 84-94, fair 65-83 and poor \<64 |
| Change in semiquantitative score for swelling and tenderness over time | Baseline, 2 weeks and 12 weeks | A score graded from 0 to 3; score 0 means no swelling nor tenderness and 3 means maximum swelling and tenderness |
Countries
Egypt
Outcome results
None listed