Long-term Effects of COVID-19 in Adolescents

Conditions

Covid19

Brief summary

The overarching objective for this prospective cohort study of COVID-19 in adolescents is to study the long-term effects, with particular emphasis on post-infectious chronic fatigue. A total of 500 individuals with a SARS-CoV-2 positive test will be enrolled in the acute phase of COVID-19 and followed for 6 months. A total of 100 individuals with SARS-CoV-2 negative test will be included during the same time period as a control group. Investigations include autonomic, pulmonary and cognitive assessement; a questionnaire charting symptoms, emotionality, personality, loneliness, life events and demographics; and extensive biobanking including genetic markers, viable PBMC, urine, feces and hair. A subgroup of 40 SARS-CoV-2 positive and 20 SARS-CoV-2 negative individuals will also undergo detailed cardiological examination by echocardiography. Primary endpoints are fatigue at 6 months as assessed by the Chalder Fatigue Scale and post-COVID-19 syndrome cases at 6 months according to the WHO definition

Lise Beier Havdal, Joel Selvakumar, Lise Lund Berven, Tonje Stiansen-Sonerud, Henrik Zetterberg et al. (8 authors)

Frontiers in Neurology2024-02-072 citations

10.3389/fneur.2024.1345787

Neurological Involvement in COVID-19 Among Non-Hospitalized Adolescents and Young Adults

Lise Beier Havdal, Lise Lund Berven, Joel Selvakumar, Tonje Stiansen-Sonerud, Truls Michael Leegaard et al. (9 authors)

Frontiers in Neurology2022-06-2220 citations

10.3389/fneur.2022.915712

Inflammatory Markers, Pulmonary Function, and Clinical Symptoms in Acute COVID-19 Among Non-Hospitalized Adolescents and Young Adults

Lise Lund Berven, Joel Selvakumar, Lise Beier Havdal, Tonje Stiansen-Sonerud, Gunnar Einvik et al. (10 authors)

Frontiers in Immunology2022-02-0928 citations

10.3389/fimmu.2022.837288

Interventions

OTHERNo active intervention (observational only)

No active intervention (observational only)

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

12 Years to 25 Years

Healthy volunteers

No

Inclusion criteria

* Positive SARS-CoV-2 test/negative SARS-CoV-2 test * Age 12 - 25 years * Living in the counties of Oslo or Viken, Norway * \< 28 days since onset of first symptom

Exclusion criteria

* Hospitalised due to COVID-19 * Pregnancy * Lack of consent

Design outcomes

Primary

Measure	Time frame	Description
Fatigue	6 months follow-up	Total sum score on the Chalder Fatigue Scale (range 0 - 33, lower scores means less fatigue, ie. better outcome)
Post-COVID-19 syndrome caseness	6 months follow-up	Post-COVID-19 syndrome casesness according to the WHO definition (issued Sept. 2021; hence, this endpoint was added during the course of the study, but prior to database lock.)

Countries

Norway

Outcome results

None listed