Doppler Ultrasonographic Assessment of Fetal Internal Thoracic Artery Indexes

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04686240

Enrollment

150

Registered

2020-12-28

Start date

2021-01-31

Completion date

2021-06-30

Last updated

2020-12-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Fetal; Circulation, Pregnancy Related

Brief summary

The aim of this study is to assess the feasibility of visualizing the internal thoracic artery (ITA), establishing the normogram for ITA pulsatility index (PI), resistance index (RI) and acceleration/ejection time (AT/ET) at 24-32 weeks.

Detailed description

Background: The internal thoracic artery arises from the subclavian artery as the first branch. It travels downward on the inside of the rib cage and then gives off six main branches; mediastinal, thymic, pericardiacophrenic, sternal, perforating and intercostal branches. In literature, there are so many articles that have been focused on thymus size in pregnancies complicated with diabetes mellitus, fetal growth restriction, preterm rupture of membranes and so on. To the best of our knowledge, there is no paper about fetal ITA whose branch are feeding vessel of thymus and ITA Doppler velocity. The arteries supplying the thymus are branches of the internal thoracic, and inferior thyroid arteries. As far as it has been known, growing of a tissue depends on increased blood flow. Before detecting possible blood-flow changes in fetuses complicated with great obstetrics patologies, the investigators should obtain normal values of ITA Doppler velocity.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

17 Years to 45 Years

Healthy volunteers

Yes

Inclusion criteria

* singleton pregnancy * having no fetal anomalies * healthy pregnant women age \>17 and \<45 years * between 24th-32nd gestational weeks

Exclusion criteria

* fetuses with congenital aneuploidy or structural malformation * underlying chronic diseases * pregnant women complicated with gestational diabetes, Type 1-2 DM, hypertension (pregnancy-induced; chronic; preeclampsia), malignancy * pregnancy complicated with preterm premature rupture of membranes, preterm labour, fetal growth restriction and another obstetric complication

Design outcomes

Primary

Measure	Time frame	Description
Doppler indices for internal thoracic artery	Between 24th and 32nd gestational weeks	Doppler indices (pulsatility index, resistance index, acceleration and ejection time)
assessment of fetal thymus size	Between 24th and 32nd gestational weeks	volume and perimeter and transvers diameter

Contacts

Primary Contactbetül yakıştıran, MD

btlengin@gmail.com+905464296321

Backup Contactaykan yücel, professor

aykanyucel@gmail.com+905323851110

Outcome results