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Factors Associated With Failed Spinal Anesthesia for Cesarean Delivery

Factors Associated With Failed Spinal Anesthesia for Cesarean Delivery, a Retrospective Case-control Study

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT04685980
Enrollment
440
Registered
2020-12-28
Start date
2020-12-25
Completion date
2021-08-31
Last updated
2023-04-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anesthesia; Adverse Effect, Cesarean Section Complications

Keywords

Spinal anaesthesia, cesarean section

Brief summary

The aim of this study is to reveal the factor associated with failed spinal anaesthesia in cesarean delivery. We conduct the retrospective case-control study to elucidate the involving factors.

Detailed description

Spinal anaesthesia is the anaesthetic technique of choice of patients undergoing cesarean delivery due to its rapid onset, good reliability and good efficacy. However, the inadequate or failed spinal anaesthesia can occur. The previous literatures revealed incidence of failed spinal anaesthesia was as high as 0.5-6%. Failure of spinal anaesthesia leads to numerous maternal and neonatal consequences. Those failed spinal anaesthesia patients required general anaesthesia with endotracheal tube which may cause several complications such as hypoxia, difficult intubation, failed intubation and pulmonary aspiration. Also, a recent network meta-analysis showed general anaesthesia decreasing neonatal Apgar score. The factors that associated with failed spinal anaesthesia in cesarean delivery has been studied. The amount of local anaesthetic, needle type, patients' body mass index (obesity), and experiences of the anaesthetist performing spinal block influenced the failure of spinal anaesthesia. The details and factors of failed spinal anaesthesia in our hospital was scarce. It has not yet been published in the literature. Therefore, the aim of this study is to reveal the factor associated with failed spinal anaesthesia in cesarean delivery. We conduct the retrospective case-control study to elucidate the involving factors.

Interventions

PROCEDUREspinal anaesthesia with local anaesthetic and intrathecal morphine

Patients undergoing cesarean delivery and received spinal anaesthesia with local anaesthetic and intrathecal morphine

Sponsors

Mahidol University
Lead SponsorOTHER

Study design

Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE

Eligibility

Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* Age \>,= 18 years * Undergoing cesarean delivery * Failed spinal anaesthesia and received general anaesthesia with endotracheal tube

Exclusion criteria

* Gestational age \< 24 weeks * Received combined spinal-epidural anaesthesia * Received peripheral nerve blockade

Design outcomes

Primary

MeasureTime frameDescription
AgeAt starting operationFactors involving failed spinal anaesthesia for cesarean delivery: patient age
Body mass indexAt starting operationFactors involving failed spinal anaesthesia for cesarean delivery: patient body mass index (BMI) : weight and height will be combined to report BMI in kg/m\^2
Anaesthesiologist performing spinal anaesthesiaAt starting anaesthesiaFactors involving failed spinal anaesthesia for cesarean delivery: Anaesthesiologist performing spinal anaesthesia (resident or consultant)
Time starting of operationAt starting operationFactors involving failed spinal anaesthesia for cesarean delivery: at which time cesarean delivery starting to performed eg. in office hour or out of office hour

Secondary

MeasureTime frameDescription
Incidence of failed spinal anaesthesia for cesarean deliveryAt starting operationIncidence of failed spinal anaesthesia for cesarean delivery

Countries

Thailand

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026