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Intraoperative Norepinephrine Versus Fresh Frozen Plasma in Patients Undergoing HIPEC to Reduce Renal Insult

Intraoperative Norepinephrine Versus Fresh Frozen Plasma in Patients Undergoing HIPEC to

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT04683614
Enrollment
60
Registered
2020-12-24
Start date
2020-10-20
Completion date
2022-05-28
Last updated
2022-06-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anesthesia

Brief summary

comparing the effect of low dose norepinephrine infusion versus fresh frozen plasma in patients undergoing HIPEC to reduce renal insult

Detailed description

To compare the efficacy of maintaining intraoperative hemodynamic stability through infusing low dose norepinephrine versus fresh frozen plasma in patients undergoing cytoreductive surgery and heated intraperitoneal chemotherapy in cancer patients undergoing cytoreductive surgery and heated intraperitoneal chemotherapy

Interventions

DRUGNorepinephrine

5 mic/kg/hr norepinephrine

BIOLOGICALFresh frozen plasma

early administration of fresh frozen plasma

Sponsors

National Cancer Institute, Egypt
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No

Inclusion criteria

* ASA I and II * World Health Performance Status ≤2 * scheduled for CRS/HIPEC operations

Exclusion criteria

* patient's refusal * allergy to any of the used drugs * impaired renal or liver functions

Design outcomes

Primary

MeasureTime frameDescription
Renal insult24 hoursCreatinine level increase 0.3 mg/dl above preoperative baseline

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026