The Prevalence and Characteristics of Adrenal Incidentaloma

The Prevalence and Characteristics of Adrenal Incidentaloma: A Prospective Study

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04682938

Enrollment

25356

Registered

2020-12-24

Start date

2020-11-20

Completion date

2021-11-30

Last updated

2022-08-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Adrenal Incidentaloma, Prevalence

Keywords

Prevalence, characteristics, adrenal incidentaloma

Brief summary

To investige the prevalence, characteristics and prognosis of adrenal incidentalomas in Chinese adults.

Detailed description

With the development of imaging detection technology and its wide application in clinic, the detection rate of adrenal incidentaloma (AI) has been greatly improved. Most AI are benign and do not have the function of autonomic hormone secretion, but about 20% of them have function and can secrete adrenal hormone autonomously. Studies based on biopsy reports show that the prevalence of AI is about 2%, and the prevalence of AI detected by CT scan is 1% - 4.5%. However, most of these studies are retrospective, and there may be selection bias and other confounding factors. There is no large sample prospective study on the prevalence of AI in the general population. The purpose of this study is to prospectively include patients with adrenal incidentaloma in community physical examination population, and evaluate their function and prognosis. The research results will provide new evidence for standardized diagnosis and treatment of adrenal incidentaloma in the future.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 78 Years

Healthy volunteers

Yes

Inclusion criteria

·On weekdays, the first 100 individuals, aged 18 to 78 years, taking health checkup in the Community Health Examination Center were invited to take part in the study.

Exclusion criteria

* with known adrenal diseases; * with continuous steroids or drug treatment that might influence cortisol secretion ordexamethasone metabolism and could not be stopped * refuse to participate in the study.

Design outcomes

Primary

Measure	Time frame	Description
Prevalence and Characteristics of Adrenal Incidentaloma	1 years	To investigate the prevalence and characteristics of Adrenal Incidentaloma in general population in China

Secondary

Measure	Time frame	Description
Steroid hormones in the function of Adrenal Incidentaloma	1 years	prospectively evaluate potential predictive role of combined detection of multiple steroid hormones in the function of Adrenal Incidentaloma

Countries

China

Outcome results