Corona Virus Infection
Conditions
Brief summary
Vitamin C (ascorbic acid) is a water-soluble vitamin having anti-inflammatory, immunomodulatory, anti-oxidative, antithrombotic and antiviral properties. Considering these effects vitamin C should have beneficial impact in patients suffering from sepsis and acute respiratory distress syndrome (ARDS). The current study is designed to assess the beneficial effects of Vitamin C in COVID-19 infected patients.
Interventions
DRUGVitamin C
mega dose is given to the selected critically ill patients
Sponsors
University of Lahore
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
critically ill patients admitted in ICU
Exclusion criteria
allergic to Vitamin C didnt given the consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Partial pressure of Oxygen in arterial blood to fraction of inspired Oxygen (P/F ratio) | 1 and 4th day |
| Survival analysis | 28 days follow up |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Length of Hospital stay | Admission to discharge | — |
| Need for intubation | 28 days | number of intubations needed in both groups. |
| Inflammatory markers | before the start of treatment (day 1) and on day 4 | comparison of the inflammatory markers, CRP, D.Dimer, Procalcitonin, LDH, TLC and hematological variables at day four after the intervention started. |
| APACHE II score | before the start of treatment (day 1) and on day 4 | — |
Countries
Pakistan
Outcome results
None listed