Analysis of BPA Concentration in Serum in Women of Reproductive Age With Autoimmune Thyroid Disease

Analysis of Bisphenol A Concentration in Serum in Women of Reproductive Age With Autoimmune Thyroid Disease

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04682340

Enrollment

Registered

2020-12-23

Start date

2020-12-22

Completion date

2022-01-19

Last updated

2022-01-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Graves Disease, Hashimoto Disease, Hyperthyroidism, Hypothyroidism

Keywords

bisphenol A, BPA, Hashimoto's Disease, Graves' Disease

Brief summary

The aim of the study is to assess the relationship between the concentration of bisphenol A in serum and selected parameters of thyroid function in women of reproductive age with thyroid dysfunction - Hashimoto's disease and Graves' disease.

Interventions

DIAGNOSTIC_TESTSerum BPA

Serum BPA levels will be compared between women with autoimmune thyroid disease and normal women.

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 45 Years

Healthy volunteers

Inclusion criteria

* Graves' disease or Hashimoto's disease (positive thyroid autoantibody) * Control group: thyroid autoantibody negative, normal thyroid function * Women aged 18 to 45 in both the control group and experimental group

Exclusion criteria

* Pregnancy and lactating women * Previous or planned treatment with 131I or thyroidectomy * The use of drugs affecting the thyroid function (lithium, amiodarone, interferon a, sodium nitroprusside, sunitinib, sorafenib, iodine contrast, antibiotics / antifungals / antivirals (for at least 4 weeks prior to recruitment to the study), which do not result from the treatment of thyroid disease (levothyroxine, thyreostatic drugs, glucocorticoids) * Active malignancy * Other autoimmune diseases * Other endocrine diseases * Patients with severe liver, kidney or heart failure

Design outcomes

Primary

Measure	Time frame
Comparison of serum BPA levels between the group with AITD and control group	Dec 2020 - April 2021

Secondary

Measure	Time frame	Description
The association between serum BPA levels and serum thyroid hormone levels in the AITD group	Dec 2020 - April 2021	To determine the association between serum BPA concentrations and serum thyroid hormone levels in adult women

Countries

Poland

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026