Transmission, Patient-Professional
Conditions
Keywords
aerosol generating procedure, high-flow nasal cannula, nebulization, aerosol therapy
Brief summary
Several clinical procedures have been described as aerosol generating procedure (AGP), including nebulization, high-flow nasal cannula oxygen therapy, noninvasive ventilation, and bronchial hygiene treatment, etc. However, the understanding on the transmission risk of these treatments is still unclear, particularly the methods to reduce the airborne particulate concentrations during these treatments are still lacking. This study is aimed to compare different modalities in reducing airborne particulate concentrations during these aerosol generating procedures, in order to find the most effective method to reduce particle concentrations, ultimately to decrease the transmission risk and protect health care providers.
Interventions
DEVICEFilter
Filter is used to capture any individual bacteria or viruses that might be suspended within inhaled or exhaled gases
DEVICEScavenger face tent
A face tent is connected to a vacuum resource to continuously suction the exhaled gas from the subject, in order to reduce the transmission risk of virus or bacteria
Sponsors
Rush University Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
OTHER
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
• Ages 18-65, Male or Female
Exclusion criteria
* Chronic lung disease, including asthma, COPD, etc. * Upper airway anatomical abnormities * Pregnancy * Uncontrolled Diabetes, hypertension, or untreated thyroid disease * Has any of the following symptoms in the last 21 days: sore throat, cough, chills, body aches for unknown reasons, shortness of breath for unknown reasons, loss of smell, loss of taste, fever at or greater than 100 degrees Fahrenheit. * COVID-19 test positive within 21 days.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| aerosol particle concentrations at 1 foot away from subject's face | 5 mins | aerosol particle concentrations will be recorded continuously for 5 mins during the use of each device at 1 foot away from subject's face |
| aerosol particle concentrations at 3 feet away from subject's face | 5 mins | aerosol particle concentrations will be recorded continuously for 5 mins during the use of each device at 3 feet away from subject's face |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| subject's comfort | 5 minutes after using the device | subject's comfort will be self-evaluated using a visual numerical scale (VNS) ranging between 1 (very uncomfortable) and 5 (very comfortable) |
Countries
United States
Outcome results
None listed