Abdomen, Acute, Acute Kidney Injury, Myocardial Injury, Pulmonary Disease
Conditions
Brief summary
Explorative study to investigate potential predictors of myocardial injury, acute kidney injury and pulmonary disorder after acute high-risk abdominal surgery.
Detailed description
The main issues are: * To investigate if coronary calcification predisposes the development of myocardial injury and causes an increased mortality rate. * To evaluate the predictive value of NT-pro-BNP in relation to the development of MINS and the mortality rate. * To evaluate the predictive value of different biomarkers of AKI in relation to which patients develop AKI. * To examine the proteins, exosomes and single cell RNA during acute kidney injury in order to describe the molecular processes in the kidney during AKI. * To examine whether a chest CT scan without contrast enhancement will change treatment decisions in the acute gastrointestinal patient compared with a chest x-ray.
Interventions
DIAGNOSTIC_TESTChest CT without contrast enhancement and chest X-ray
Chest CT without contrast enhancement and chest X-ray as supplement to diagnostic abdominal CT
Sponsors
Bispebjerg Hospital
University of Southern Denmark
Nordsjaellands Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adults (≥18 years). * Patients included in the AHA regimen undergoing CT on suspicion acute high-risk abdominal disorder e.g.g bowel obstruction GI perforation or ischemia, and need of emergency abdominal surgery, either laparoscopic surgery or laparotomy. * Able to speak Danish. In case Danish was not spoken an interpreter was used to obtain the informed consent. * Able to give informed consent.
Exclusion criteria
* Patients who cannot give informed consent to participate in the study 15 minutes after receiving verbal information regarding the study. * Known chronic kidney disease requiring dialysis at the time of admission (only
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Proportion of patients with myocardial injury af non-cardiac surgery | 30 days | Troponin-I above specified level and dynamic changes |
| Mortality rate | 30 days | Postoperative mortality |
| Acute kidney Injury | 30 days | According to KIDGO criteria |
| Proportion of patients with pulmonary pathology | 1 day | Findings (including incidental) on a chest x-ray and chest CT scan without contrast enhancement |
| Proportion of patients with pulmonary complications | 30 days | Postoperative complications |
Countries
Denmark
Outcome results
None listed