Working Memory
Conditions
Brief summary
This project will assess the feasibility of traveling wave transcranial alternating current stimulation (tACS) to modify working memory performance and large-scale brain connectivity in surgical epilepsy patients.
Interventions
DEVICETranscranial alternating current stimulation
Traveling wave transcranial alternating current stimulation will be applied at 4 Hz and 23 Hz over frontal and parietal brain areas in a randomized counterbalanced order.
Sponsors
National Institute of Mental Health (NIMH)
University of Minnesota
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. the patient can consent for themselves; 2. the patient has or is scheduled for surgically implanted electrodes for the purposes of phase II epilepsy surgical evaluation; 3. age 18+ years old;
Exclusion criteria
1\. diminished capacity to consent;
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Working memory outcomes | Immediate effect during stimulation | Changes in working memory performance as measured with the N-back task (quantified with d-prime) during stimulation. |
| Electrophysiological outcomes | Immediate effect during stimulation | Changes in spectral power and coherence of the local field potentials during transcranial electric stimulation relative to no stimulation periods. |
Countries
United States
Outcome results
None listed