Alopecia Areata
Conditions
Keywords
alopecia areata, Microneedling, Cryotherapy
Brief summary
This study is randomized comparative analytical prospective study that included patients with mild and moderate alopecia areata. Patients was divided into two groups Patients in the first group underwent Superficial cryotherapy using dimethyl ether and propane (DMEP) at -57C (Cryotherapy group). Patients in the second group underwent Microneedling (Microneedling group). A total of six sessions were done at 2 weeks interval. Patients were followed-up for next 3 months to evaluate the persistence of hair regrowth after therapy. Patients were assessed at baseline and during follow up using photography, Dermoscopy, SALT score and regrowth scale.
Interventions
PROCEDUREDMEP kit
Superficial Cryotherapy using dimethyl ether and propane (DMEP) at -57C
DEVICEDermapen
Under aseptic precautions, the dermapen was moved on the alopecic patches diagonally, vertically and horizontally 4 to 5 times in each direction Pin point bleeding was taken as an end point
Sponsors
Sohag University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
Patients will be divided into two groups (randomly assigned and comparably cross matched for age and sex) Cryotherapy group (No.= 50): Superficial cryotherapy using dimethyl ether and propane (DMEP) at -57C Microneedling group (No. = 50): Microneedling
Eligibility
Sex/Gender
ALL
Age
4 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* ِAlopecia areata patients
Exclusion criteria
* Alopecia totalis and universalis * ِAge less than four years. * ِPregnancy or breast-feeding. * ِActive infection at the site alopecia patch(s). * ِInflammation ate site of the alopecia patches * ِIntolerance to cold. * ِAssociated systemic illness such as thyroid, pernicious anaemia, diabetes mellitus, autoimmune connective tissue diseases. * ِPrevious treatment for alopecia areata over the last three months.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Regrowth Scale | Change in regrowth scale from baseline to 3 months follow after end of sessions | 0 score (regrowth \< 10%) no response 1. score (regrowth 11-25%) poor response 2. score (regrowth 26-50%) fair response 3. score (regrowth 51-75%) satisfactory response 4. score (regrowth ≥ 75%) excellent response. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| SALT score | Change in salt score from baseline to 3 months follow after end of sessions | SALT score is the sum of the percentage of hair loss in all the abovementioned areas. For example, if the percentage hair loss in vertex, right profile, left profile, and posterior aspect is 20, 30, 40, and 50% respectively; then, SALT score = (20 × 0.4) = (30 × 0.18) + (40 × 0.18) + (50 × 0.24) = 8 + 5.4 + 7.2 + 12 = 32.6. |
Countries
Egypt
Outcome results
None listed