Genetic Studies in Familial Dementia

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04680013

Enrollment

4884

Registered

2020-12-22

Start date

2007-06-01

Completion date

2024-10-29

Last updated

2025-03-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Alzheimer Disease, Early Onset, Alzheimer Disease, Late Onset, Dementia, Dementia of Alzheimer Type, Mild Cognitive Impairment

Keywords

Memory loss

Brief summary

The purpose of this study is to identify genetic factors that contribute to or cause dementia (loss of memory) and related disorders across all ages and ethnic groups. This includes a number of neurological diseases such as early and late-onset Alzheimer disease, mild cognitive impairment, and other dementias.

Interventions

None listed

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

1. 18 years and older 2. Patients diagnosed with dementia, their family members and unrelated healthy controls without dementia.

Exclusion criteria

1\. Individuals with competing diagnosis such as: Amyotrophic lateral sclerosis, Frontotemporal lobar degeneration, Multiple system atrophy, Corticobasal degeneration, Progressive Supranuclear Palsy, Huntington's disease, traumatic brain injury, drug or alcohol abuse, or schizophrenia, etc. (unless family members of a dementia affected individual).

Design outcomes

Primary

Measure	Time frame	Description
Correlation between genetic factors and Alzheimer disease, dementia, and related phenotypes.	5 years	Genetic factors will be measured through genome-wide genotyping arrays and/or whole-genome sequencing, and then correlated with Alzheimer disease and related phenotypes, such as cognitive impairment, functional impairment, and relevant biomarkers. .

Countries

United States

Outcome results