Minimal Residual Disease Evaluation on Cryopreserved Ovarian Fragments in Younger Patients Treated for Acute Myeloid Leukemia

Pilot Study to Assess Minimal Residual Disease on Cryopreserved Ovarian Fragments in Younger Patients Treated for Acute Myeloid Leukemia

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04679285

Acronym

FERTILAM

Enrollment

Registered

2020-12-22

Start date

2021-04-26

Completion date

2022-09-04

Last updated

2025-12-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Myeloid Leukemia

Keywords

Acute myeloid leukemia, Fertility preservation, Ovarian cryopreservation, Minimal residual disease

Brief summary

Cryopreservation of ovarian cortex represents an option for fertility preservation in patients diagnosed with acute myeloid leukemia and requiring allogeneic stem cell transplantation. This pilot study aims to evaluate the minimal residual disease on ovarian fragments harvested before allogeneic stem cell transplantation at the time of complete remission.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

FEMALE

Age

2 Years to 40 Years

Healthy volunteers

Inclusion criteria

* Patient diagnosed with AML * At least one molecular marker identified at AML diagnosis * Patients who undergo ovarian tissue cryopreservation for fertility preservation in complete remission, before hematopoietic stem cell transplantation.

Exclusion criteria

* Other diagnostic * No marker available at AML diagnosis * No bone marrow/ovarian fragment available at the time of complete remission

Design outcomes

Primary

Measure	Time frame
Percentage of patients without detectable MRD in ovarian tissue	Up to 6 months

Secondary

Measure	Time frame
Percentage of patients with MRD detected in ovarian tissue and bone marrow.	Up to 1 month

Countries

France

Outcome results