Evaluation of Blood Biomarkers as an Indicator of Delayed Neurocognitive Recovery

Evaluation of Blood Biomarkers as an Indicator of Delayed Neurocognitive Recovery After Cardiac Surgery

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04679259

Enrollment

Registered

2020-12-22

Start date

2021-01-06

Completion date

2025-10-29

Last updated

2026-01-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative Cognitive Dysfunction

Brief summary

Delayed neurocognitive recovery is defined as a cognitive decline arising after surgery. In the present study, the authors evaluate the level of D-Amino Acid Oxidase, D-serine and Serine racemase in blood as an indicator of delayed neurocognitive recovery after cardiac surgery.

Interventions

DIAGNOSTIC_TESTBlood sampling for assessment of the level of D-Amino Acid Oxidase, D-serine and Serine in blood

Blood sampling is done before surgery and at 1, 2, and 7 day after surgery. The level of D-Amino Acid Oxidase, D-serine and Serine in blood are assessed.

DIAGNOSTIC_TESTNeurocognitive test

Neurocognitive test is performed before surgery and at 7 day after surgery

DIAGNOSTIC_TESTAssessment of delirium

Postoperative delirium is assessed daily during 7 days after surgery.

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

55 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients scheduled for elective cardiac surgery

Exclusion criteria

* MMSE \<24 * History of psychological or neurological diseases * Illiteracy * Preoperative delirium * Vision and hearing impairment

Design outcomes

Primary

Measure	Time frame	Description
Change of concentration of D-Amino Acid Oxidase in blood at 1, 2, and 7 day after surgery	Before surgery and at 1, 2, and 7 day after surgery	Blood level of D-Amino Acid Oxidase is assessed.

Secondary

Measure	Time frame	Description
Concentration of D-serine in blood	Before surgery and at 1, 2, and 7 day after surgery	Blood level of D-serine is assessed.
Concentration of Serine racemase in blood	Before surgery and at 1, 2, and 7 day after surgery	Blood level of Serine is assessed.
Occurrence of delayed neurocognitive recovery	Before surgery and at 7 day after surgery	Neurocognitive assessment

Countries

South Korea

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026