Celiac Disease, Type 1 Diabetes
Conditions
Keywords
Type 1 Diabetes, Celiac Disease, Diabetes, Celiac, Gluten, Autoantibodies
Brief summary
The CASCADE Study (Combined Antibody Screening for Celiac and Diabetes Evaluation) is an observational study whose primary goal is to show that population-based screening for advanced prediction of type 1 diabetes (T1D) and celiac disease (CD) is feasible to prevent diabetic ketoacidosis (DKA), improve celiac disease diagnosis, and ultimately gain public health acceptance to facilitate future prevention. It has two arms, a Birth Cohort and a Kids (cross sectional) Cohort.
Interventions
DIAGNOSTIC_TESTCombined Risk Score
Several factors will be analyzed to assign each subject combined risk score. This will assess the subject's risk of developing Type 1 Diabetes and/or Celiac Disease.
Sponsors
University of Exeter
Pacific Northwest Research Institute
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
1 Days to 7 Years
Healthy volunteers
Yes
Inclusion criteria
* Child must be between 0 to 8 months in age or between 4 to 7 years in age. Child must be born in the state of Washington.
Exclusion criteria
\-
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Diagnosis of Type 1 Diabetes | 5 years |
| Diagnosis of Celiac Disease | 5 years |
Secondary
| Measure | Time frame |
|---|---|
| Severity of disease at diagnosis | 5 years |
Countries
United States
Outcome results
None listed