Thrombelastography, Acute Liver Injury, Acute Decompensation, Platelet
Conditions
Brief summary
Ineffective hemostasis or a paradoxical prothrombotic state of Acute-on-chronic liver disease (ACLF) has been well established. Thrombelastography measures the dynamics of thrombin production and provides a global assessment of coagulation incorporating the cumulative effect of the interactions at various levels between plasma components and cellular component of coagulation. Through the previous studies(NCT03281278 and NCT04119973), we found that ACLF patients with high ADP inhibition rate had high 28-day mortality.This study aims to validate that high ADP inhibition rate only occurs in patients with liver failure and is related to the severity of the disease.
Interventions
None listed
Sponsors
Nanfang Hospital, Southern Medical University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
1. chronic liver disease: including chronic liver hepatitis patients without cirrhosis, compensated cirrhosis patients, decompensated cirrhosis patients and non-alcoholic fatty liver disease patients. 2. ALI(acute liver injury): including \[ALT \> 3 ULN(upper limited of normal),AST \> 3 ULN or TB \> 2 ULN within 1 week before enrollment\] or AD(acute decompensation) : including \[(having ascites, hepatic encephalopathy and/or bacterial infection within 1 month before enrollment)\].
Exclusion criteria
1. those who had hepatocellular carcinoma or other types of malignancies; 2. obstructive biliary diseases or other disease lead to bilirubin evaluation; 3. those who had acute hemorrhage one week before admission 4. those who received platelet, cryo transfusion or plasmapheresis one week before admission 5. pregnancy and breastfeeding 6. those who received liver transplantation or kidney transplantation; 7. combine with other disease lead to organ failure including heart failure (NYHA IV),respiratory failure（PaO2\<60mmHg),renal insufficiency(CKD 5) and conscious disturbance (GCS\<8) 8. readmission; 9. death within 24 hours.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| 28-day mortality | 28-day | death within 28-day |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| 28-day progression | 28-day | progressed to EASL defined ACLF |
| 90-day mortality | 90-day | death within 90-day |
Countries
China
Outcome results
None listed