High Intensity Interval Exercise, Stroke
Conditions
Keywords
Cerebral Blood Velocity, Cerebral Autoregulation
Brief summary
The objective of this project is to study the cerebrovascular response to a single bout of high intensity interval exercise (HIIT) in 25 individuals with chronic stroke compared to 25 age- and sex- matched healthy controls (CON). We will enroll 25 young healthy adults (CONyoung) as a reference group. Our hypothesis is that the cerebrovascular response in individuals with chronic stroke will be significantly lower: 1) during a single bout of HIIT, and 2) during the recovery immediately following and 30 minutes after HIIT, compared to CON. This study has 2 visits at the University of Kansas Medical Center Research in Exercise and Cardiovascular Health Laboratory. For the first visit, we will perform questionnaires about heart health, physical activity and overall health. Participants will then complete a submaximal exercise test on a seated stepper. Participants will also have a familiarization session to practice HIIT. The second visit will include cerebrovascular measures before, during, immediately after, and 30 minutes after performing HIIT.
Interventions
BEHAVIORALSingle, acute bout of high intensity interval exercise
Individuals will perform a single bout of high intensity interval exercise on a seated recumbent stepper. Participants will perform the pattern of high intensity interval exercise by switching between 1-minute high intensity stepping followed by 1-minute light, active recovery stepping for a total of 10 minutes.
Sponsors
University of Kansas Medical Center
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
Chronic Stroke Inclusion Criteria: * Age 40-80 years old * Treated for stroke 6 months to 5 years ago * Performs \<150 minutes of moderate intensity exercise per week * Able to answer consenting questions and follow a 2-step command Chronic Stroke
Exclusion criteria
* Stroke etiology due to COVID-19 pathology. * Symptoms of COVID-19 and/or Positive COVID-19 test within the past 3 months * Unable to stand from a sitting position without physical assistance * Recent joint replacement/surgery/poor motor control that limits ability to perform exercise on a recumbent stepper * Insulin injection dependent diabetes * Dependent on supplementary oxygen * History of other neurological disease (Multiple Sclerosis, Alzheimer's disease, Parkinson's disease) * Unable to find TCD signal on the stroke-affected or non-affected MCA. CON Inclusion Criteria: * Matched age ± 5 years to participant with chronic stroke * Matched sex to participant with chronic stroke * Performs \<150 minutes of moderate intensity exercise per week * Able to answer consenting questions and follow a 2-step command CON
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in Middle Cerebral Artery Blood Velocity (MCAv) | Pre-to-post intervention, ~40 minutes | blood velocity traveling through the middle cerebral artery measured using the transcranial Doppler ultrasound. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in Dynamic Cerebrovascular Autoregulation (dCA) | Pre-to-post intervention, ~40 minutes | Ability of the cerebrovascular system to maintain MCAv independent of changes in peripheral blood pressure. Measured using transcranial Doppler ultrasound and mean arterial pressure measured with every heart beat. |
Countries
United States
Outcome results
None listed