BCG Vaccination Reaction, LTBI, TB
Conditions
Brief summary
TB-reactive immune cells will be tested in a multiparametric flow cytometry to distinguish an immune response for antigens of Mycobacterium spp. in TB disease/latent infection or a reaction after BCG vaccine.
Detailed description
The goal of this project is the verification of current cytometric panel of detection antibodies in a wider panel of stimulative immunodominant antigens for CD4+ and CD8+ T cells in combination with adjuvants 2 in a in vitro activating test.
Interventions
DIAGNOSTIC_TESTBlood draw
Blood draw and the analysis of blood in laboratory
Sponsors
Charles University, Czech Republic
Thomayer University Hospital
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
4 Years to 70 Years
Inclusion criteria
active TB, contact with TB infection in previous 3 months before the study \-
Exclusion criteria
* HIV positive patients
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Peer-review publication of results of our study | 2 years |
Secondary
| Measure | Time frame |
|---|---|
| Creation of new diagnostic tool and his comparision with existing IGRA test (QTF-GP and TST) | 2 years |
Countries
Czechia
Contacts
Primary ContactPetra Hadlová, MGR
Backup ContactKarolína Doležalová, MD
Outcome results
None listed