Common Cold
Conditions
Brief summary
The purpose with this study is to investigate the preventative effect of a supplement containing a combination of probiotic bacteria and fungi as well as zinc on the common cold. The hypothesis is that it will shorten the duration, alleviate the severity of symptoms or even decrease the number of infectons during the intervention period. This study is a randomzed placebo controlled human study were healthy adults will consume the supplement for three months.
Interventions
DIETARY_SUPPLEMENTProbiotic
The participants will consume 2 capsules daily for three months
DIETARY_SUPPLEMENTPlacebo
The participants will consume 2 capsules daily for three months
Sponsors
Coradil AB
Lund University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Masking description
Double-blinded
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy adults
Exclusion criteria
* Diagnosed gastrointestinal disorders * Autoimmune diseases or immuno compromized * Antibiotic treatment in the last month
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Symptoms severity | Three months | Decrease in the severity of symptoms will be determined using a common cold questionnaire. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Composition of gut and oral microbiome | Three months | Change in gut and oral microbiome will be measured using 16SrRNA and 18SrRNA sequencing |
| IgA | Three months | Changes in levels of IgA in saliva and/or feces will be measured using ELISA |
| Duration of symptoms | Three months | Decrease in duration of cold will be determined using a common cold questionnaire |
| Number of colds | Three months | Decrease in number of colds will be determined using a common cold questionnaire |
Countries
Sweden
Outcome results
None listed