Absolute Quantification in Bone Scintigraphy

Absolute Quantification in Bone Scintigraphy: Phantom Evaluation and Clinical Application in Patients Undergoing Follow-up for Vertebral Fractures.

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04671238

Acronym

QUANTOSS-3D

Enrollment

Registered

2020-12-17

Start date

2020-01-01

Completion date

2021-02-01

Last updated

2022-09-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Scintigraphy Quantification

Keywords

bone scintigraphy, absolute quantification, Standard Uptake Value

Brief summary

While absolute quantification in 18F-FDG PET (Positon Emission Tomography) is widely used in clinical routine, absolute quantification in SPECT (Single Photon Emission Computed Tomography) is under development and its clinical interest remains to be demonstrated. Recent studies carried out on bone scan recordings show the potential interest of quantification indexes such as SUV (Standard Uptake Value).

Detailed description

In oncology, bone scan studies have reported significantly higher SUV values for secondary bone lesions compared with benign osteoarticular lesions , and some have even defined an SUVmax threshold value that points to prostatic bone metastases.

Interventions

DEVICESPECT CT

SPECT/CT scan of the spine as part of a vertebroplasty

Study design

Observational model

CASE_ONLY

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients with recent vertebral fractures: 1. who have had at least two SPECT/CT scan scans of the spine as part of a pre-vertebroplasty check-up, 2. for which fracture dates were known.

Exclusion criteria

1. Minor person 2. Person opposing the use of their data (Posters in waiting rooms explaining that the patient must object if they do not wish their data to be used)

Design outcomes

Primary

Measure	Time frame	Description
To validate the absolute bone scan quantification in a retrospectively selected patient population	After 1 year	Analysis of SUV variation on at least 2 bone scans: Variation of the SUV over time on scans of patients with spinal fractures

Secondary

Measure	Time frame	Description
To calibrate the tomographic images from the gamma camera	1 day	Calibrate the tomographic images from the gamma camera to obtain a volume activity in Bq/mLand densities
To evaluate the attenuation correction on phantoms of different density	1 day	SUV absolute quantitation index (SUVmax, SUVpeak, SUVmean).
To evaluate absolute quantification on phantoms	1 day	Evaluate absolute quantification on phantoms with objects of different volumes

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026