Nephrolithiasis, Urosepsis
Conditions
Keywords
endotoxin, fever, infectious complications, endourology, percutaneous nephrolithotomy
Brief summary
The aim of the study is to establish an infectious risk stratification system based on pre-and post-operative blood endotoxin profile.
Interventions
None listed
Sponsors
University of Miami
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adults that is able to consent (≥ 18 years of age) * Scheduled to undergo PCNL at Uhealth tower and Jackson Memorial Hospitals * not currently immunosuppressed \[White blood count (WBC) \>= 2, not on immunosuppressive medications\]
Exclusion criteria
* unable to consent and \< 18 years of age * currently immunosuppressed (WBC \< 2, not on immunosuppressive medications)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of participants at each endotoxin activity level after surgery. | Day 1 (within 30 minutes postoperative) | The endotoxin activity level assessed from blood samples will be categorized as low (\<0.40), intermediate (0.40-0.59) or high (≥0.60) endotoxin activity level. Analysis will be done via Endotoxin Activity Assay (EAA). |
| Corelation of endotoxin activity level with post-operative infectious complication | up to 24 hours | infectious complications include fever, and signs and symptoms of systemic inflammatory response syndrome as evaluated by treating physician. |
Countries
United States
Contacts
CONTACTHemendra N Shah
PRINCIPAL_INVESTIGATORHemendra N Shah
University of Miami
Outcome results
None listed