End Stage Kidney Disease
Conditions
Keywords
sarcopenia, pain, physical performance
Brief summary
Many systems such as the cardiovascular, pulmonary, musculoskeletal, hematological, immunological, gastrointestinal, central nervous system are affected due to decreased kidney function. The aim of this study was to investigate the relationship between physical performance and sarcopenia, peripheral muscle strength, activities of daily living, cognitive functions, physical activity level, fragility, pain in hemodialysis patients.
Detailed description
A high prevalence of sarcopenia has been reported in end stage kidney disease. The incidence of sarcopenia increases with age. Muscle atrophy is caused by an imbalance between the anabolic and catabolic processes in chronic kidney disease. Sarcopenia and physical inactivity progress synergistically. Decreased physical performance is associated with sarcopenia. In hemodialysis patients, daily physical activity level and physical performance decrease. Cognitive impairment is common in chronic kidney disease. Uremic toxins can cause a decrease in cognitive function. One of the most important problems associated with hemodialysis is pain and pain negatively affects functional capacity and quality of life.
Interventions
None listed
Sponsors
Hacettepe University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Inclusion criteria
* Having been diagnosed with end stage kidney disease * Receiving hemodialysis for more than 3 months * Being clinically stable * Volunteering to participate in the research
Exclusion criteria
* Having an orthopedic disease that may affect functional capacity * Having cardiac event in the past 3 months
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Sarcopenia | 5 minutes | Sarcopenia will be evaluated using SARC-F questionnaire. For SARC-F, a total score of ≥ 4 indicates sarcopenia. |
| Physical performance will be evaluated using Short physical performance battery. | 10 minutes | The total score of Short physical performance battery ranges from 0 to 12. |
| Physical performance will be evaluated using 1 minute sit to stand test. | 5 minutes | 1 minute sit to stand test, the maximum number of repetitions within the established time was recorded |
| Pain level | 5 minutes | Pain will be evaluated using Short-form McGill Pain questionnaire |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Peripheral muscle strength | 5 minutes | Knee extensor and hand grip strength will be evaluated using dynamometer. |
| Activities of daily living | 10 minutes | Activities of daily living will be evaluated using Barthel Index for Activities of Daily Living.The total score is100 and higher scores mean a better outcome. |
| Cognitive function | 10 minutes | Cognitive function will be evaluated using Standardized Mini-Mental State Examination. The test is a 30-point screening tool. Higher scores mean a better outcome. |
| Physical activity level | 5 minutes | Physical activity level will be evaluated using International Physical Activity Questionnaire-Short Form |
| Fragility | 5 minutes | Fragility will be evaluated using the five Fried frailty criteria (unintentional weight loss, exhaustion, weakness, slowness, low physical activity). The total score is interpreted as follows: 0 non-frail, 1-2 pre-frail and 3-5 frail |
Contacts
Primary ContactMerve Firat
Outcome results
None listed