Covid19, Periodontitis
Conditions
Keywords
COVID-19, Human microbiome, Oral microbiome, SARS-CoV-2 infection
Brief summary
An observational study of patients with COVID-19 confirmed cases (with various degrees of severity) and controls. Oral and nasal swabs will be taken from 150 patients (50 with mild form and 50 with severe form of COVID-19 with or without mechanical ventilation, 50 healthy controls).
Interventions
OTHERSwab
PCR test for SARS-CoV2, oral and nasal swab
Sponsors
DermBiont, Inc.
University College London Hospitals
The Whittington Hospital NHS Trust
Eastman Dental Insitute and Hospital
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
1. Must provide written informed consent 2. Subjects have to be tested (PCR) positive or negative for SARS-CoV2 infection 3. Must be able to provide oral and nasal swabbing within 48 hours of polymerise chain reaction (PCR) test results
Exclusion criteria
a. Under the age of 18 years old
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Oral microbial signature | Day 1 | To assess the oral microbial signatures that relates to SARS-CoV2 in patients with no, mild and severe disease. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Nasal microbial signature | Day 1 | To assess the nasal microbial signatures related to SARS-CoV2 in patients with no, mild and severe disease and to assess the role of the oral expression of ACE2-Ang II system during SARS-CoV2 in relation to disease outcome (mild, severe COVID). |
Countries
United Kingdom
Contacts
Primary ContactJeanie Suvan
Outcome results
None listed