Cardiovascular Diseases, Contrast-induced Acute Kidney Injury
Conditions
Keywords
contrast-induced acute kidney injury, contrast-associated acute kidney injury, contrast media, cardiovascular diseases, computer tomography
Brief summary
The aim of the study is to assess the role of statins and different dosage regimens in the prevention of contrast-induced acute kidney injury in patients with cardiovascular diseases requiring intravenous contrast media administration before computer tomography
Interventions
DRUGAtorvastatin
To compare the preventive role of low- and high-dose statin regimens in the prevention on contrast-induced acute kidney injury in statin-naive patients with cardiovascular diseases undergoing computer tomography with intravenous contrast media administration
Sponsors
I.M. Sechenov First Moscow State Medical University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Written informed consent * Indications for computer tomography with intravenous contrast media administration * Cardiovascular diseases (arterial hypertension, arrhythmia etc)
Exclusion criteria
* Pregnancy * Statin therapy before inclusion in the study * Acute coronary syndromes * Contraindications for statins administration * Patients with chronic kidney disease stages 4-5 * Contraindications for computer tomography with contrast media administration * Nephrotoxic drugs use (NSAIDS, vancomycin etc)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Contrast-induced acute kidney injury | 48-72 hours after contrast media administration | Contrast induced acute kidney injury is defined as the 25% rise (or 0,5 mg/dl) of serum creatinine from baseline assessed 48 hours after administration of contrast media. |
Countries
Russia
Outcome results
None listed