Mother-Infant Interaction
Conditions
Keywords
neonates, oxytocin, late preterm, stress, family-centered intervention
Brief summary
The aim of this study is to measure the variation of oxytocin and cortisol levels in the saliva of premature neonates and their mother after sensorial stimuli.
Detailed description
The aim of this study is to measure the variation of oxytocin and cortisol levels in the saliva of neonates with gestational age ranging from 32 to 34 completed weeks and in the saliva of their mothers. The measurements are taken before and after sensorial stimuli including mother voice exposure +/- tactile distraction for 10 minutes. The two interventions are performed between day 5 and day 12 after birth and 24 to 48 hours apart. Each child is randomised in a group depending on order of the two interventions. Investigators hypothesize that an increase in the oxytocin/cortisol ratio will be occurred in neonates after hearing their mothers and that simultaneous tactile stimulation will mitigate that effect. Concomitantly, the neonate's vital signs and his facial expressions are recorded during interventions. The mothers anxiety level is assessed PSS-NICU questionnaire given before the first and after the second intervention.
Interventions
OTHERVoice alone
mother's voice without tactile stimuli
OTHERVoice + tactile stimuli
mother's voice with tactile stimuli
Sponsors
University Hospital, Geneva
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
OTHER
Masking
NONE
Intervention model description
prospective randomised crossover study
Eligibility
Sex/Gender
ALL
Age
32 Weeks to 35 Weeks
Healthy volunteers
No
Inclusion criteria
* Newborn gestational age 32 0/7 weeks to 34 6/7 weeks * Born at university hospital Geneva * French speaking parents * Out of incubator * Signed consent
Exclusion criteria
* Newborn with one of the above conditions: * Congenital malformation * intraventricular hemorrhage grade III or IV * white matter abnormality * anti-epileptic or sedative drugs * altered consciousness level * Infant requiring respiratory support * psychiatric disorders in the mother or antenatal use of psychoactive drugs * Bilateral absent otoacoustic emissions and/or auditory evoked potential * Parents refusal to participate
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Oxytocin/cortisol ratio | at baseline and 10 minutes after intervention | Change in salivary oxytocin/cortisol ratio in response to the intervention |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Vital signs | at baseline, during and 10 minutes after intervention | Change in heart rate and respiratory rate in response to the intervention |
| Facial expression analysis | at baseline, during and 10 minutes after intervention | Response of neonate to intervention analysed by standardized neonatal facial coding system score, measured on video recording before, during and after the intervention |
| mother anxiety and mother infant bond | at baseline and 10 minutes after intervention | Level of the mothers anxiety and her bond to the infant analyzed using NICU-PSS questionnaires |
Countries
Switzerland
Outcome results
None listed