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Effect of Fasting on the Non-invasive Measurement of the Body's Water Compartments

Effect of Fasting on the Non-invasive Measurement of the Body's Water Compartments

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT04665349
Enrollment
81
Registered
2020-12-11
Start date
2019-11-20
Completion date
2020-10-13
Last updated
2020-12-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dehydration, Perioperative Complication

Brief summary

Preoperative fasting is defined as refraining from food for at least 6 hours and clear fluids for at least 2 hours prior to anaesthesia. On the one hand, it is a procedure that reduces the risk of aspiration of food content and the occurrence of Mendelson's syndrome, and on the other hand, it was considered to be the cause of disturbances in water management in patients undergoing general anaesthesia. However, reports from recent years have found that moderate preoperative fasting does not influence the risk of hypovolemia in anesthetized patients. It is also known that in fasting people the total body water is reduced. Thus, it can be assumed that there are mechanisms causing the movement of extravascular water into the lumen of blood vessels. For several years, the Body Composition Monitor (BCM) device for non-invasive measurement of the volume of individual water compartments of the human body has been available on the market. It allows to determine the volume of total body water, intracellular body water and extracellular body water. It is mainly used during dialysis, but it can also be used in other circumstances that require the determination of the body's hydration status. The principle of this method is based on non-invasive bioimpedance measurement with the use of 4 electrodes placed on two extremities. The aim of the study is to determine whether there is a fluid shift between the intracellular and extracellular compartments in people undergoing preoperative fasting. Examination of this issue would allow for the development of hypothesis regarding the optimal perioperative fluid therapy. If there was a shift of fluid from the intracellular space, it seems more rational to supplement fluid deficiencies resulting from starvation with a 5% glucose solution. If, on the other hand, no fluid shift from the intracellular space was detected, which would suggest shifts within the extracellular space, it would be advisable to hydrate the patient with crystalloid solutions.

Interventions

After 10 hours of fasting participants will receive per os 400 milliliters of Nutricia Pre-op

Sponsors

Medical University of Gdansk
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
18 Years to 40 Years
Healthy volunteers
Yes

Inclusion criteria

* American Society of Anesthesiology (ASA) general condition assessment 1 or 2

Exclusion criteria

* Chronic kidney disease * Circulatory failure * Phenylketonuria * History of hypoglycaemic episodes or any carbohydrate metabolism disorders.

Design outcomes

Primary

MeasureTime frameDescription
Amount of total body waterChanges form baseline after 10 hours of fasting and after 2 hours of pre-op administrationMeasurements will be done with Fresenius Body Composition Monitor
Extracellular to intracellular water ratioChanges form baseline after 10 hours of fasting and after 2 hours of pre-op administrationMeasurements will be done with Fresenius Body Composition Monitor

Countries

Poland

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 21, 2026