PEP on a Skin Graft Donor Site Wound

Inclusion criteria

Main Criteria for Inclusion: 1. Males and females 18-75 years of age. 2. Requiring at least two 20-40 cm2 split-thickness skin grafts by a licensed surgeon or dermatologist 3. Skin graft that meets all the following criteria: 1. Each graft site has a size of 20-40 cm2 (but can be up to 90 cm2 if found to be clinically indicated during the graft procedure) 2. Located anywhere on the body (with exception of oral mucosal membranes) 3. Split-thickness skin graft wound depth of between 8/1000-14/1000 inch 4. Study donor sites are ≥ 1 cm apart 4. Ability to safely undergo skin graft harvest procedure 5. Capacity to provide informed consent 6. Ability to comply with protocol 7. Subject is judged, by the clinical investigator, to be healthy as evidenced by lack of clinically significant abnormal findings on medical history, physical examination, vital signs, and clinical laboratory tests 8. Subject is able and willing to return to study site for all follow-up visits Main Criteria for Exclusion: 1. Actively undergoing chemotherapy treatment (localized radiation treatment is allowed if it is not on the skin graft donor site and no active cancer is present) 2. Known history of MRSA (methicillin-resistant Staphylococcus aureus) 3. Known hypersensitivity to aprotinin (Trasylol®) 4. Subjects who are positive for hepatitis B surface antigen (HbsAg), hepatitis C antibody or human immunodeficiency virus (HIV) 5. Any known allergy or sensitivity to adhesive dressings (e.g., Tegaderm) 6. Clinically significant cardiovascular, pulmonary, renal, endocrine, hepatic, neurological, psychiatric, immunological, gastrointestinal, hematological, or metabolic disease that is, in the opinion of the investigator, not stabilized or may otherwise impact the results of the study 7. Participation in another interventional clinical study or trial in the past 30 days or concurrent participation in another interventional clinical study or trial 8. Subjects with poorly controlled diabetes mellitus (Hemoglobin A1c \[HbA1c\] ≥ 8%) 9. Subjects with known peripheral neuropathy, or known concomitant vascular problems (such as peripheral artery disease, arterial insufficiency, or venous hypertension) or calciphylaxis 10. Subjects with burns covering ≥ 30% of Total Body Surface Area 11. Currently on or planned to receive hyperbaric wound therapy 12. Pregnant or lactating female subjects 13. Sexually active woman of childbearing potential who is unwilling to use approved contraception method for 3 months after receiving dose of investigational drug 14. Prisoners