GastroIntestinal Bleeding
Conditions
Brief summary
Acute gastrointestinal bleeding is potentially lethal in liver cirrhosis. Accurate assessment of prognosis is critical in a timely fashion. A novel model, CAGIB score, has been developed based on our Chinese multicenter retrospective study. Now, a prospective, international multicenter, observational study will be performed to further compare the performance of CAGIB versus Child-Pugh and MELD scores for evaluating the in-hospital mortality of patients with liver cirrhosis and acute gastrointestinal bleeding.
Interventions
None listed
Sponsors
Xingshun Qi
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Patients with liver cirrhosis; 2. Patients with acute gastrointestinal bleeding presenting with hematemesis, melena, and/or hematochezia; 3. Adults (age≥18 years old).
Exclusion criteria
1. Components of Child-Pugh, MELD, and CAGIB scores are not available; 2. In-hospital outcomes are not evaluable.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Mortality | An average of 1-6 weeks, from admission to discharge | Death caused by any events during hospitalizations. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Failure to control bleeding within 5 days | 5 days | Failure is defined as death or need to change therapy defined by one of the following criteria within 5 days: 1) Fresh hematemesis or nasogastric aspiration of ≥100 ml of fresh blood ≥2 h after the start of a specific drug treatment or therapeutic endoscopy; 2) Development of hypovolaemic shock; 3) 3g drop in hemoglobin (9% drop of hematocrit) within any 24 hours period if no transfusion is administered. |
Countries
Brazil, China, Germany, India, Italy, Mexico, Turkey (Türkiye), United States
Contacts
Primary ContactXingshun Qi, Dr.
Backup ContactZhaohui Bai, Dr.
Outcome results
None listed