Alkaline Phosphatase, Calcium, COVID-19 Infection, Parathyroid Gland, Parathyroid Hormone, Phosphorus
Conditions
Brief summary
COVID-19 infection causes a hypersensitive immune reaction and widespread inflammation in various organs of the body, especially through cytokines in the lungs. This cytokine-mediated widespread inflammation can also affect the parathyroid glands, resulting in impaired parathyroid secretion. Researchers evaluated the levels of parathyroid hormone, calcium, phosphorus, and alkaline phosphatase in patients hospitalized for COVID-19 infection. Researchers excluded patients on intensive care therapy and patients with known parathyroid disease. The researchers examined the association of parathyroid hormone secretion with COVID-19 disease, white blood cells, neutrophil / lymphocyte ratio, C reactive protein, fibrinogen, procalcitonin, ferritin, and D-dimer in these patients. The researchers compared the parathyroid hormone level of healthy people without COVID-19 infection and known parathyroid disease with the parathyroid hormone level of Covid-19 patients.
Detailed description
The coronavirus-2 (SARS-COV-2) virus, which can cause severe acute respiratory syndrome through the droplet, has caused the global Coronavirus 19 (COVID-19) pandemic. COVID-19 infection can be asymptomatic or lead to serious illness and even death. This virus causes a hypersensitive immune reaction and varying degrees of widespread inflammation through cytokines in various organs of the body, mainly the lungs. Cytokine-mediated widespread inflammation caused by the virus may also affect the parathyroid glands, causing their functions to deteriorate. Thus, it may cause changes in parathyroid hormone secretion. The researchers evaluated the results of serum parathyroid hormone, calcium, phosphorus, alkaline phosphatase tests in patients who were symptomatic and hospitalized with COVID-19 infection. Participants also evaluated the relationship of parathormone with white blood cells, neutrophil / lymphocyte ratio, c reactive protein, fibrinogen, procalcitonin, ferritin, and D-dimer in these patients. The researchers compared the parathyroid hormone levels of patients with COVID-19 infection with the parathyroid hormone levels of healthy individuals without COVID-19 infection and parathyroid disease. So the investigators looked for differences in parathyroid hormone levels between both groups. Researchers did not include patients in the intensive care unit and patients with known parathyroid disease.
Interventions
DIAGNOSTIC_TESTVenous blood was collected for biochemistry testing
From the people in the healthy control group, 10 ml of venous blood was collected from the venous vein in the forearm of all individuals in the study. Parathyroid hormone, calcium, phosphorus, alkaline phosphatase levels were measured from this blood.
Sponsors
Didem Ertorul
Bezmialem Vakif University
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 100 Years
Healthy volunteers
Yes
Inclusion criteria
* To accept research. * Being over the age of 18. * COVID 19 test results to be positive. * Not taking parathyroid disease medication before. * Receiving inpatient treatment in the COVID service in the hospital.
Exclusion criteria
* Not accepting research. * Be under the age of 18. * Negative COVID 19 test results for patients. * COVID patients treated as outpatient. * Parathyroid disease in the healthy control group.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Comparison of parathyroid hormone between groups | 90 days | In the study, serum parathyroid hormone results of the Covid patient group and non-Covid control groups were recorded and compared statistically. |
| Comparison of calcium between groups | 90 days | In the study, serum calcium results of the Covid patient group and non-Covid control groups were recorded and compared statistically. |
| Comparison of phosphorus between groups | 90 days | In the study, serum phosphorus results of the Covid patient group and non-Covid control groups were recorded and compared statistically. |
| Comparison of alkaline phosphatase between groups | 90 days | In the study, serum alkaline phosphatase results of the Covid patient group and non-Covid control groups were recorded and compared statistically. |
| White blood cells (WBC) results of Covid 19 patient group | 90 days | In the study, serum WBC results were recorded in Covid 19 patient groups. |
| Neutrophil / lymphocyte ratio (N/LO) results of Covid 19 patient group | 90 days | In the study, serum N/LO results were recorded in Covid 19 patient groups. |
| C-reactive protein (CRP) results of Covid 19 patient group | 90 days | In the study, serum CRP results were recorded in Covid 19 patient groups. |
| Fibrinogen results of Covid 19 patient group | 90 days | In the study, serum fibrinogen results were recorded in Covid 19 patient groups. |
| Procalcitonin results of Covid 19 patient group | 90 days | In the study, serum procalcitonin results were recorded in Covid 19 patient groups. |
| Ferritin results of Covid 19 patient group | 90 days | In the study, serum ferritin results were recorded in Covid 19 patient groups. |
| D-dimer results of Covid 19 patient group | 90 days | In the study, serum D-dimer results were recorded in Covid 19 patient groups. |
Countries
Turkey (Türkiye)
Outcome results
None listed