Hookah Smoking, Secondhand Aerosol, Vaping, Vascular Stiffness
Conditions
Brief summary
In the United States, secondhand smoke is the third leading preventable cause of death. Flavored hookah (waterpipe) tobacco smoking, a highly social activity common in hookah bars, is a key source of SHS exposure. While smoke-free air laws have decreased exposure to secondhand smoke, the majority of laws do not include hookah smoking. Thus, as a social outlet for youth and young adults, hookah smoke exposure may harm non-smokers, including women of reproductive age or pregnant, hookah bar workers, children, and individuals with heart and lung disease. While more is known on the acute effects of active hookah smoking and the literature is emerging on active e-hookah vaping, little is known about the acute vascular effects of secondhand exposure to hookah smoke and aerosol. The study aims to examine the acute effects of secondhand exposure of hookah smoke and aerosol on endothelial and vascular function. Eligible volunteers will be invited to participate in a total of 3 study visits (2-3 hours each): e-hookah aerosol exposure, charcoal-heated hookah smoke exposure and smoke-free room air. Non-invasive blood pressure and blood flow measurements will be taken before and after the exposure sessions.
Interventions
OTHERCombustible Hookah Smoke
Exposure to combustible hookah smoke for a duration of 60 minutes.
OTHERElectronic Hookah Aerosol
Exposure to electronic hookah aerosol for a duration of 60 minutes.
OTHERClean Room Air
Exposure to room air for a duration of 60 minutes.
Sponsors
University of California, Los Angeles
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
21 Years to 49 Years
Healthy volunteers
Yes
Inclusion criteria
* 21-49 years old * Never a smoker: do not use any tobacco products or nicotine delivery systems, including cigarettes, cigars (traditional and filtered), cigarillos, hookah, smokeless tobacco (i.e., loose snus, moist snuff, dip, spit, or chewing tobacco), pipe tobacco, snus pouches, dissolvable tobacco or vaping. * no evidence of cardiopulmonary disease by history/physical * blood pressure (BP) \< 140/90 mmHg * resting heart rate (HR) \< 100 bpm * BMI \>18 or \< 30kg•m2 * no prescription medication * No exposure to environmental tobacco smoke for at least one week prior to the study date.
Exclusion criteria
* exhaled carbon monoxide \>6 ppm * (+) pregnancy test * other conditions deemed unsafe to participate, such as breastfeeding
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Flow-Mediated Dilation (FMD) | Pre- and post- the 60-minute exposure sessions | Using ultrasound, FMD of the brachial artery induced by reactive hyperemia, will be used to measure endothelium-dependent vasodilator function. Baseline diameter and velocity will be recorded for 45 seconds and resumed 30 seconds before cuff deflation and continuously for 2 minutes after deflation to obtain true peak vasodilatory response. |
| Arterial stiffness | Pre- and post- the 60-minute exposure sessions | Using applanation tonometry, pulse wave velocity will be used to measure cebtral arterial stiffness. |
Countries
United States
Outcome results
None listed