Osteoarthritis, Knee
Conditions
Brief summary
In this study, a total of 219 subjects from the MOON nested cohort will be studied at CCF, Vanderbilt and OSU, Table 1. Among them, some will have added MRI during their 10-year visit for the MOON study. Some subjects who finished their 10-year visit for the MOON Onsite study already will be called back to have MRI. PROMs and other information of these subjects will be collected through the MOON study.
Detailed description
In this study, a total of 219 subjects from the MOON nested cohort will be studied at CCF, Vanderbilt and OSU, Table 1. Among them, some will have added MRI during their 10-year visit for the MOON study. Some subjects who finished their 10-year visit for the MOON Onsite study already will be called back to have MRI. PROMs and other information of these subjects will be collected through the MOON study. In addition, 30 age-, sex- and BMI-matched control subjects (10 from each site) will be recruited and scanned for MRI. PROMs (KOOS, IKDC, Marx, SF-36) will be collected from these controls. Among the 10 controls recruited locally at CCF, five will also travel to OSU and Vanderbilt to be scanned at the other two sites for cross-validation among the three sites. There will be a separate consent for the 5 controls that will be traveling to each of the 3 sites for the scans. The remaining 25 controls will be tested at only their local site.
Interventions
OTHERNo Intervention - Observational study with MRI
90 minute MRI of the knees
Sponsors
The Cleveland Clinic
Vanderbilt University Medical Center
Ohio State University
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
22 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* Enrolled in MOON Onsite Study * 12-33 years old at baseline (22-45 years for this study); * ACL tear during a sport; no previous knee injury; * No graft rupture during follow-up; * No history of surgery on the contralateral knee; * No MRI contraindications
Exclusion criteria
* History of surgery on contralateral knee * Afraid of enclosed spaces
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Cartilage health status | At 10-years after ACL reconstruction | Quantitative MRI will be used to quantify cartilage health. Specifically, cartilage MR T1rho and T2 relaxation times will be quantified for cartilage of the knee that had ACL reconstruction, and compared to the contralateral uninjured knee. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Patient reported outcomes | At 10-years after ACL reconstruction | Pain score (0-100) evaluated using Knee injury and Osteoarthritis Outcome Score (KOOS) |
Countries
United States
Contacts
PRINCIPAL_INVESTIGATORXiaojuan Li, PhD
The Cleveland Clinic
Outcome results
None listed