Child Development
Conditions
Brief summary
A study of the relation between genetic biomarkers and child development in Taiwan.
Detailed description
The interaction between gene and environment (G×E) can be a very complicated process that influences child development. As a pilot study of child development biomarkers, this study investigates genes related to child development.
Interventions
None listed
Sponsors
Chang Gung Memorial Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
1 Years to 18 Years
Healthy volunteers
Yes
Inclusion criteria
of Healthy Child: * Age 2-18 y/o * Agree to sign informed consent
Exclusion criteria
of Healthy Child: * Central nervous system disease * Neuromuscular Disorders * Congenital Abnormality * Genetic Disease * Dysesthesia * Hearing Impairment Inclusion Criteria of Child with developmental delay: * Patients with Language Disorder * Age 2-18 y/o * Agree to sign informed consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Gene test (WES4) | baseline | Whole-Exome Sequencing (Use Genome Analysis Toolkit (GATK) to screen out the variant discovery and genotyping.) |
| Gene test (Mircoarray) | baseline | Microarray (Use Axiom Genome-Wide TWB 2.0 Array Plate (TWB 2.0) to analyze SNPs of disease-related biomarkers.) |
| Gene test (WES1) | baseline | Whole-Exome Sequencing (Use Burrows-Wheeler Aligner (BWA) 85 to screen out the variant discovery and genotyping.) |
| Gene test (WES2) | baseline | Whole-Exome Sequencing (Use Samtools86 to screen out the variant discovery and genotyping.) |
| Gene test (WES3) | baseline | Whole-Exome Sequencing (Use Picard to screen out the variant discovery and genotyping.) |
| Scores of cognitive function 1 | baseline | Bayley Scales of Infant and Toddler Development (Scores from 0 to 140, higher scores mean a better outcome.) |
| Scores of cognitive function (2 y/o to 6 y/o) | baseline | Wechsler Preschool and Primary Scale of Intelligence (Scores from 0 to 200, higher scores mean a better outcome.) |
| Scores of cognitive function (6 y/o to 16 y/o) | baseline | Wechsler Intelligence Scale for Children (Scores from 0 to 200, higher scores mean a better outcome.) |
| Scores of cognitive function 3 | baseline | Test of Nonverbal Intelligence-Fourth Edition (Scores from 0 to 60, higher scores mean a better outcome.) |
| Scores of cognitive psychological function | baseline | Cantab MOT, PAL, SWM, SOC tests |
| Scores of language function | baseline | Peabody Picture Vocabulary Test-Revised (Scores from 0 to 124, higher scores mean a better outcome.) |
| Scores of language function 2 | baseline | Preschool Language Impaired Scale(PLS)/Language Impaired Scale(LS) (PLS: Scores from 0 to 65, higher scores mean a better outcome. LS: Scores from 0 to 73, higher scores mean a better outcome.) |
| Scores of general development | baseline | Comprehensive Developmental Inventory for Infants and Toddlers (Higher scores mean a better outcome.) |
| Scores of social behavior 1 | baseline | Clancy Behavior Scale (Scores from 0 to 42, lower scores mean a better outcome.) |
| Scores of social behavior 2 | baseline | Swanson, Nolan, and Pelham, Version IV (Lower scores mean a better outcome.) |
| Scores of motor ability 1 | baseline | The Berry-Buktenica Developmental Test of Visual-Motor Integration (Scores from 0 to 81, Higher scores mean a better outcome.) |
| Scores of motor ability 2 | baseline | Measure of Grip and Grasp (Higher scores mean a better outcome.) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Scores of participation(>6 y/o) | baseline | Children Assessment of Participation and Enjoyment and Preferences for Activity of Children (Higher scores mean a better outcome.) |
| Scores of activities | baseline | Functional Independence Measure for Children (Scores from 18 to 126, higher scores mean a better outcome.) |
| Scores of quality of life | baseline | Pediatric Quality of Life Inventory TM (Scores from 0 to 102, higher scores mean a better outcome.) |
| Scores of participation(2-5 y/o) | baseline | Assessment of Preschool Children's Participation (Scores from 0 to 45, higher scores mean a better outcome.) |
Countries
Taiwan
Contacts
Primary ContactChia-Ling Chen, Phd
Outcome results
None listed