Refractory Uremic Pruritis
Conditions
Brief summary
Patients will be randomly assigned into 2 groups: 1. Group A: (20 patients) will receive NB UVB phototherapy 3 sessions per week for 2 months. 2. Group B: (20 patients) will receive pregabalin oral therapy (50mg after each dialysis session) for 2 months.
Interventions
DEVICENB UVB phototherapy
ultraviolet phototherapy sessions
DRUGPregabalin
oral medication
Sponsors
Alexandria University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
20 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
1. Age: 20-60 years. 2. End stage renal disease (the last stage(stage 5) of chronic disease which means kidneys are only functioning at 10 to 15 percent of their normal capacity and dialysis or kidney transplant is necessary to stay alive). 3. Refractory uremic pruritis.
Exclusion criteria
1. Other causes of pruritis (Dermatological or systemic) e.g. atopic, cholestatic liver disease. 2. Photosensitivity. 3. Contraindication or allergy to pregabalin. 4. Patients on antipruritic drugs e.g. antihistamines, steroids, emollients, opioid agonists.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| 5 D-itching scale | two month | assessment of degree, duration, direction, disability and distribution of itching |
Countries
Egypt
Contacts
Primary Contactmarwa eldeeb
Outcome results
None listed