Relationship Between FODMAPs and GVHD

Relationship Between the Utilization and Degradation Rate of FODMAPs by Intestinal Flora and GVHD

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04660487

Enrollment

100

Registered

2020-12-09

Start date

2020-12-01

Completion date

2026-12-01

Last updated

2025-12-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Graft Versus Host Disease

Brief summary

With the stem cell transplanting increasing, patients which effected with GVHD were also increased. To evaluation the relationship between FODMAPs and GVHD, Bone marrow transplant patients were recruited.

Detailed description

The feces were collected from the patients who had been successfully transplanted after bone marrow transplantation. After 24 hours of culture in the culture medium, the degradation rate of FODMAPs was detected, and the relationship between the degradation rate and the occurrence time and degree of GVHD was observed

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 60 Years

Healthy volunteers

Inclusion criteria

1. Clinical diagnosis of AML,ALL,MDS or MM Disease; 2. Must be treated with bone marrow transplantation; 3. The transplanted bone marrow was successfully planted

Exclusion criteria

1. Gastrointestinal diseases； 2. Age\>60; or Age\<10； 3. Probiotics or prebiotics were taken before enrollment

Design outcomes

Primary

Measure	Time frame	Description
Occurrence of GVHD	90 days	The occurrence time and degree of GVHD

Countries

China

Contacts

Primary Contactxiaofei qi

qixf-sz@hotmail.com+13812616208

Backup ContactDepei Wu

wudepei@suda.edu.cn+13812616208

Outcome results