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CORONADO (Circulating tumOur pROtein quaNtification cApillary blooD cOvid-19)

Circulating Tumour Protein Quantification From Capillary Blood for Patient Selfsampling and Safe Remote Monitoring of Multiple Myeloma During COVID-19

Status
UNKNOWN
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT04659252
Enrollment
70
Registered
2020-12-09
Start date
2021-03-04
Completion date
2021-12-01
Last updated
2021-03-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Multiple Myeloma

Brief summary

The coronavirus (COVID-19) pandemic has brought severe challenges for myeloma patients. Myeloma patients are considered ultra-high risk for COVID-19 and fall into the strictest group for shielding. When on treatment, but also during times of active surveillance, patients have to regularly and frequently leave shielding and visit the hospital for blood tests to monitor their disese. This is specifically for quantification of circulating tumour protein biomarker tests for paraprotein (PP) and/or serum free light chains (sFLCs) by specialised biochemistry units. This research aims to evaluate the potential use of an at-home patient administered technique to sample blood. The purpose of the blood sampling technique is to monitor your disease status. We want to test if it is possible to monitor a patient's disease status using this alternative blood collection method when compared to monitoring disease status using the traditional blood collection methods (venous blood sampling). The new VAMS method is not intended to be used interchangeably or will not replace the current method. This study is to evaluate an alternative sample type that may be used to improve the patient pathway, especially during these uncertain times.

Interventions

OTHERn/a - samples collected along routine care samples only

This is a non-interventional study.

Sponsors

Royal Marsden NHS Foundation Trust
CollaboratorOTHER
Institute of Cancer Research, United Kingdom
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
21 Years to No maximum
Healthy volunteers
No

Inclusion criteria

1. A diagnosis of a B-cell dyscrasia 2. Measurable disease by serum free light chain assay 3. Signed informed consent

Exclusion criteria

1. Patients \<21 years of age 2. Cognitive impairment 3. Non-B Cell Dyscrasia patients

Design outcomes

Primary

MeasureTime frameDescription
Validated FLC6 monthsValidated FLC method for use with VAMS that conforms to ISO15189:2012 accreditation

Countries

United Kingdom

Contacts

Primary ContactChloe Burrows
chloe.burrows@rmh.nhs.uk02089156773
Backup ContactHaemato-oncology Research Team
HaemoncGT@rmh.nhs.uk

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026