Chronic Kidney Disease, Thyroid Dysfunction
Conditions
Brief summary
A higher prevalence of thyroid disease has been associated with chronic kidney disease (CKD), and subclinical hypothyroidism seems to be the most common dysfunction. The aim is to evaluate thyroid function and autoimmunity in patients with CKD stages 3, 4 and 5. Cross-sectional study to be carried out on patients with stages 3 and 4 in a Nephrology outpatient clinic. Thyroid function is evaluated by measuring thyroid stimulating hormone (TSH), free thyroxine, free triiodothyronine and antithyroperoxidase antibodies (TPOAb) levels.
Detailed description
Cross-sectional study to be carried out on patients with stages 3, 4 and 5 in a Nephrology outpatient clinic. Thyroid function is evaluated by measuring thyroid stimulating hormone (TSH), free thyroxine, free triiodothyronine and antithyroperoxidase antibodies (TPOAb) levels. Free Thyroxine (FT4) will be measured by liquid chromatography tandem mass spectrometry and electrochemiluminescence immunoassay in order to compare methods in this population. The glomerular filtration rate was estimated (eGFR) by the Chronic Kidney Disease Epidemiology Collaboration formula (CKD-EPI), and the CKD stages were defined according to the Kidney Disease Improving Global Outcomes directives (KDIGO).
Interventions
DIAGNOSTIC_TESTThyroid function
laboratorial thyroid tests
Sponsors
Rio de Janeiro State University
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to 100 Years
Inclusion criteria
Patients over 18 years old with CKD stages 3 and 4 were included in the study. \-
Exclusion criteria
1) acute systemic inflammatory disease; 2) pituitary disease in the past or present; 3) regular treatment with amiodarone, lithium, interferon, immunosuppressive drugs and glucocorticoids; 4) previously diagnosed hypothyroidism and undergoing levothyroxine replacement. \-
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Free thyroxine (FT4) levels in chronic kidney disease | through study completion, an average of 3 years | Free thyroxine levels through two different methods |
| TSH levels in chronic kidney disease | through study completion, an average of 3 years | TSH levels |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Frequency of thyroid antibodies in chronic kidney disease | through study completion, an average of 3 years | antithyroperoxidase and antitireoglobulin antibodies |
| Free triiodothyronine (FT3) levels in chronic kidney disease | through study completion, an average of 3 years | T3 levels |
Countries
Brazil
Outcome results
None listed