Patients' Outcome With Severe or Fulminant Hepatic Insufficiency, Hospitalized in the Public Hospitals of Paris

Patients' Outcome With Severe or Fulminant Hepatic Insufficiency, Hospitalized in the Hospitals of the Assistance Publique - Hôpitaux de Paris (APHP)

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04658407

Acronym

DEVINHEF

Enrollment

18000

Registered

2020-12-08

Start date

2021-04-01

Completion date

2021-12-01

Last updated

2021-03-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Fulminating Hepatic Failure

Brief summary

The main objective is to determine the medical fate (transplanted or not and living or deceased), of patients with Severe, fulminating acute liver failure in the public hospitals of paris.

Detailed description

Severe, fulminating acute liver failure is a rare but serious disease. The overall prognosis has improved in recent years thanks to advances in medical management and liver transplantation. However, the epidemiology of this disease in France, the survival with or without liver transplantation of these patients and the factors that can influence this survival are not well known. The main objective is to determine the medical fate (transplanted or not and living or deceased), of patients with Severe, fulminating acute liver failure in the public hospitals of paris (APHP). The data will come from the APHP Health Data Warehouse

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

15 Years to No maximum

Healthy volunteers

Inclusion criteria

* Age \> 15 * Severe liver failure or toxicants that may cause a liver failure Or * (PR\<50% or INR \>1.5) And ALT \>250

Exclusion criteria

* Patients with underlying chronic liver disease * Patients with the conditions given by this following ICD (International Classification of Diseases) : B18 - E831 - K70 - K715 - K717 - K730- K731 - K732 - 738 - K74 - K753 - K758 - K760 - K761

Design outcomes

Primary

Measure	Time frame	Description
The main objective is to determine the medical fate (transplanted or not and living or deceased), of patients with Severe and fulminating acute hepatic failure within AP-HP hospitals	1 month from the diagnosis of this episode	Patient status 1 month after diagnosis of this episode (alive or dead with or without transplantation)

Secondary

Measure	Time frame	Description
Epidemiology of Severe and fulminating acute hepatic failure	Baseline	Sex Ratio M / F and cause of liver failure
Cause of death	From date of inclusion until the date of death from any cause, assessed up to 9 years	Cause of death
Analysis of Clinical Pathway	up to 1month after the diagnosis of this episode	Identification of the different services visited
Reasons for new hospitalizations with an admission date within 6 months after the diagnosis this episode	within 6 months after the diagnosis this episode	Identification by the usual code of the new hospitalization, consecutive to the episode

Countries

France

Contacts

Primary ContactPhilippe ICHAI

philippe.ichai@aphp.fr01 45 59 64 35

Outcome results