Healthy
Conditions
Brief summary
The main purpose of the study is to describe the applicability and reproducibility of functional MRI scans of the kidneys in healthy participants. Furthermore, the study examines to what extent physiological stress caused by lying in a scanner affects the renal perfusion and thus the reproducibility
Detailed description
2 groups of 10 healthy participants each are included. 1 group aged 18 to 40 and a group of participants above 60 years of age. The functional MRI sequences are performed consecutively in a protocol set up on a 1,5 T MRI scanner. In totl, 3 identical scans are being performed. 2 scans on day 1 followed by another scan 1-2 weeks later. Before and after each scan, cortisol and copeptin is controlled in a blood sample to quantify the level of physiological stress.
Interventions
DIAGNOSTIC_TESTFunctional MRI scan
Functional MRI scan: Phase contrast, BOLD, Arterial Spin Labeling, Diffusion weighted MRI, T1 mapping, T1rho mapping
Sponsors
University of Aarhus
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Age between 18 and 40 * Age of 60 or above
Exclusion criteria
* Known kidney or cardiovascular disease * Medicine of any kind, that must be taken on days of scanning * MRi incompatible implants or other contraindications to MRi * Claustrophobia * Not being able to lie still in an hour * Body weight above 110 kg or waist circumference above 95 cm * Pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Reproducibility | Results from scans performed with an interval of 1 to 2 weeks are compared | Reproducibility as a coefficient of variation |
| Physiological stress | Results from scans performed with an interval of 1 to 2 weeks are compared | Quantified by level of cortisol and copeptin in blood samples. |
Countries
Denmark
Outcome results
None listed