BPA Levels Relationship With IVF/ICSI Outcomes in Low Ovarian Reserve

Could the Consumption of Water From Plastic Bottles Affect the Embryo Grade and Clinical Pregnancy Rate Obtained With IVF/ICSI in Low Ovarian Reserve

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04654598

Enrollment

Registered

2020-12-04

Start date

2019-04-01

Completion date

2019-09-30

Last updated

2020-12-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertility, Female, Infertility Low Over Reserve, IVF

Brief summary

The relationship between BPA elevation in urine, blood, and follicle fluid and embryo quality, IVF/ICSI outcomes.

Interventions

OTHERBPA levels

BPA (bisphenol A) in urine, blood and follicle fluid samples

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

SUPPORTIVE_CARE

Masking

NONE

Eligibility

Sex/Gender

FEMALE

Age

25 Years to 45 Years

Healthy volunteers

Yes

Inclusion criteria

* patients who underwent IVF due to low ovarian reserve * patients provided urine, blood, and follicle fluid (FF) samples on the oocyte retrieval day * patients who did not smoke or use alcohol * patients did not work in the plastic industry

Exclusion criteria

* patients who underwent IVF due to unexplained infertility or tubal factor or male factor indications * patients diagnosed with endometriosis * patients with freeze-all cycles * patients having previous ovarian surgery * women with metabolic disease (such as hypertension or diabetes mellitus) * patients with a known genetic problem (male or female)

Design outcomes

Primary

Measure	Time frame	Description
Exposure to BPA	6 month	Concentrations of Bisphenol A (BPA) will be quantified in the urine, blood plasma, and follicular fluid (individual and pooled samples) by use of ELİSA test in women with low ovarian reserve

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026