Colorectal Cancer, Crohn Disease, Inflammatory Bowel Diseases
Conditions
Keywords
colorectal surgery
Brief summary
Retrospective multicentre study. All patients with a diagnosis of Crohn's disease (CD) and operated for colorectal cancer (CRC) between 01/01/2010 and 01/01/2020 will be included in the dataset. Data will include preoperative, intraoperative and postoperative variables, with long term follow up when feasible. The study will focus on a comparison between patients treated with total proctocolectomy (TPC) and patients treated with subtotal colectomy (STC) or segmental resection (SR). Primary endpoints will be oncologic outcomes, postoperative morbidity and mortality. Secondary endpoints include quality of life (QoL).
Interventions
PROCEDURETotal proctocolectomy
excision of the whole large bowel including colon and rectum and end ileostomy fashioning
PROCEDURETotal colectomy
excision of the colon with preservation of the rectum
PROCEDURESegmental colectomy
excision of a segment of colon
Sponsors
University of Rome Tor Vergata
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* All patients with a diagnosis of Crohn's disease and concomitant primary colorectal cancer who underwent surgery in an expert centre between 01/01/2010 and 01/01/2020
Exclusion criteria
* Patients who underwent non-oncologic segmental resection will be excluded from outcome analysis. * Patients with known genetic colorectal cancer syndromes (eg. Familial Adenomatous Polyposis, Hereditary Non-Polyposis ColoRectal Cancer Syndrome)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Overall Survival | 5 years | percentage of patients alive |
| disease free survival | 5 years | percentage of patients disease free |
Countries
Italy
Contacts
Primary ContactBruno Sensi, MD
Backup ContactGiuseppe S Sica, MD, PhD
Outcome results
None listed