Colon Cancer
Conditions
Keywords
postoperative complications
Brief summary
About 70% of colon cancer patients are anemic. Preoperative anemia in patients with colorectal cancer is associated with both impaired disease-free survival and overall survival. The purpose of this study is to compare the effects of preoperative iv iron substitution on postoperative recovery in preoperatively anemic (male Hb \<130, female Hb \<120) and iron deficient colon cancer patients in a prospective setup. As a primary outcome, the effect of iv-iron substitution on postoperative complications is investigated.
Detailed description
Randomized preoperative iron substitution for patient with iron deficient anemia
Interventions
DRUGFerric carboxymaltose
Iron-arm treated with Ferric carboxymaltose, non-iron arm without
Sponsors
Helsinki University Central Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 100 Years
Healthy volunteers
No
Inclusion criteria
* Age\> 18 years * Dg: Colon ca * The planned measure: the colon resection * Men: Hb \<130, women: Hb \<120 and iron deficiency (elevated TfR, low TrFesat or low ferritin)
Exclusion criteria
* hyperreactivity for Ferinject * haemochromatosis * refusal for participation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| postoperative complications | 30 days | At study, difference between arms will be evaluated: Complications are analysed using Clavien-Dindo classification https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1360123/bin/3TT1.jpg |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Need for red blood cell transfusion | 30 days | Number of Participants in need for red blood cells transfusion per arm |
Countries
Finland
Contacts
Primary ContactSuvi K Rasilainen, Md, PhD
Outcome results
None listed