Autism Spectrum Disorder
Conditions
Brief summary
In a former study, four vanilloid compounds were observed increased in the urin of autistic patients. The present study is aimed at performing a ambispective study to confirm or not these preliminary results. 70 urins from autistic children (already collected) will be compared to 70 urins of non autistic children (collected without intervention, remaining sample from the standard care), in terms of measurements of four vanilloid compounds using a GCMS apparatus.
Interventions
None listed
Sponsors
Central Hospital, Nancy, France
Study design
Observational model
CASE_CONTROL
Time perspective
OTHER
Eligibility
Sex/Gender
MALE
Age
2 Years to 14 Years
Healthy volunteers
Yes
Inclusion criteria
: For cases : * Male children aged 2 years to less than 15 years inclusive years at time of sample collection * Children with a diagnosis of autism (ICD-10 F84.0) after assessment by a child psychiatrist. For healthy chlidren: * Children aged 2 years to less than 15 years old performing an ECBU at the CHRU of Nancy as part of their care. * Patient whose ECBU is negative with respect to cytobacteriology (absence of urinary infection). * Child can be matched to a CAS
Exclusion criteria
For cases: * Children in whom one of the following pathologies is found during the anamnesis or in the clinical record : (i) renal insufficiency; (ii) urinary tract infection at the time of sampling and/or metabolic disease * Children on antibiotic treatment at the time of collection For healthy chlidren : * children whose urine culture come from one of the following departments: Pediatric Nephrology (potential risk of renal failure) or Pediatric Neurology (potential risk of neurological disorder). * with a diagnosis of autism * with a metabolic disease * children undergoing antibiotic treatment at the time of collectio
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| measurements of vanilloid compound in urins | through study completion, an average of 18 months | The primary end point is to determine if isolated or combinations of vanilloid compound measured in urin, may discriminate autistic vs non autistic childen |
Contacts
Primary ContactMarc Merten, PhD
Backup ContactJean-Luc Olivier, MD, PhD, Pr
Outcome results
None listed