Parkinson's Disease, Physical Exercise
Conditions
Keywords
Parkinson's Disease, Physical exercise, Mechanism
Brief summary
This trial is expected to recruit patients with primary Parkinson's disease and give them four consecutive weeks of aerobic exercise to observe its effect on Parkinson's disease and explore its mechanism
Detailed description
This trial is expected to recruit patients with primary Parkinson's disease who are distributed into tremor group and stiff group and give them the same kind of four consecutive weeks of aerobic exercise to observe its effect on Parkinson's disease and explore its mechanism
Interventions
BEHAVIORALaerobic exercise
Participants ride an Acon-8650 model exercise bicycle 3 times a week for 1 hour each time for four consecutive weeks
Sponsors
The First Hospital of Jilin University
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
55 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Participants were diagnosed primary PD according to the 2015 MDS diagnostic criteria * Participants are between 55 and 65 years old
Exclusion criteria
* Severe heart * liver dysfunction * kidney dysfunction * severe cognitive dysfunction * severe anxiety and depression * history of mental illness * history of cerebral infarction or ischemic attack in the past three months * acute myocardial infarction or acute coronary in the past three months * Parkinson's Pulse syndrome * medication history (drugs that improve blood circulation in the brain and increase the excitability of the nervous system)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Movement Disorder Society-United Parkinson's Disease Rating Scale (MDS-UPDRS) | changes of MDS-UPDRS score from baseline at four weeks | to assess the motor and nonmotor function of PD,0-200 scores,the higher scores mean lower function |
| Montreal Cognitive Assessing(MoCA) score | changes of MoCA score from baseline at four weeks | to assess the cognitive function of PD,0-30 scores,the higher scores mean better function |
| The Epworth Sleeping Scale(ESS) | changes of ESS score from baseline at four weeks | to assess the degree of drowsiness, 0-24 scores, the higher scores mean severe drowsiness |
| Non-Motor Symptom Scale (NMSS) | changes of NMSS score from baseline at four weeks | to assess the non-motor of PD , 0-120 scores, the higher scores mean severe non-motor damage |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| cerebral blood variation by Head MRI | changes of the cerebral blood from baseline at four weeks | to assess the cerebral blood variation by head MRI |
| cerebral blood flow velocity | changes of the cerebral blood flow velocity from baseline at four weeks | cerebral blood flow velocity is recorded using transcranial Doppler and a servo-controlled plethysmograph respectively. |
| the level of arterial blood pressure | changes of the arterial blood pressure from baseline at four weeks | arterial blood pressure is recorded using transcranial Doppler and a servo-controlled plethysmograph respectively. Both systolic and diastolic pressures will be assessed during the study period. |
| the concentration of microRNA in peripheral blood by gene chip | changes of microRNA from baseline at four weeks | to test the the concentration of microRNA in peripheral blood |
Countries
China
Outcome results
None listed