Alveolar Bone Loss, Platelet Rich Plasma
Conditions
Keywords
Dental implant, Cone Beam Computerized Tomography (CBCT).
Brief summary
To study the effect of platelet-rich plasma concentrate on marginal bone loss and bone mineral density in immediate implant placement through CBCT.
Detailed description
12 subjects were equally categorized into two groups. Group, I was the control group; whereas, the subjects in Group II received Platelet Rich Plasma (PRP) therapy. All subjects were given a standard treatment with single implant system. Inserted implants were analyzed through Cone Beam Computerized Tomography (CBCT). Records were registered at the baseline, at 12th week before functional loading and 26th week after functional loading.
Interventions
BIOLOGICALPRP injection
PRP was prepared using patient's blood and mixed with saline or mixture of calcium chloride and thrombin to form a liquid solution; in order to inject at the surgical site after placement of implant.
DEVICEAutomated blood cell separator to extract PRP
Blood was withdrawn from antecubital vein and mixed with anticoagulant. Blood sample was then centrifuged to obtain platelet rich plasma which was injected at surgical site after implant placement.
Sponsors
CMH Lahore Medical College and Institute of Dentistry
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
20 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* patients maintaining good oral hygiene, having adequate bone quantity at the implant site, uneventful extraction
Exclusion criteria
* Active infection around implant site, immunocompromised state, with current major systemic disease (uncontrolled diabetes, rheumatoid arthritis, etc.) or oral pathologies, history of bleeding disorders or on anticoagulant therapy, or patients on bisphosphonates were excluded from the study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Measurement of bone loss at baseline (12 weeks) and later at 26weeks | Baseline -before functional loading at 12 weeks & at 26 weeks- after functional loading to assess changes in marginal bone loss in sagittal view using CBCT | Measurement at mesial in mm |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Measurement of bone loss at baseline (12 weeks) and later at 26weeks | Baseline -before functional loading at 12 weeks & at 26 weeks- after functional loading to assess changes in marginal bone loss in sagittal view using CBCT | Measurement at distal in mm |
Other
| Measure | Time frame | Description |
|---|---|---|
| Bone Mineral Density | Baseline -before functional loading at 12 weeks & at 26 weeks- after functional loading to assess changes in marginal bone loss in sagittal view using CBCT | Measurement in Hounsfield number |
Countries
Pakistan
Outcome results
None listed