Blood Clot, Hemostatic Disorder, Percutaneous Coronary Intervention
Conditions
Keywords
East Asian Paradox
Brief summary
The G-NUH registry is a two-center, real-world registry of percutaneous coronary intervention in patients with significant coronary artery disease. From January 2010, PCI-treated patients from Gyeonsang National University Hospitals (Jinju & Changwon) were enrolled in this registry. The aim of this registry is to investigate long-term clinical outcomes and predictors of adverse outcomes after percutaneous coronary intervention from the academic hospitals.
Detailed description
In the G-NUH registry, the investigators have collected and measured multiple hemostatic, physiologic and laboratory measurements (on-admission & 1-month) and questionnarred from PCI-treated patients. This registry will focus on the impacts of these parameters on long-term clinical outcomes from East Asian patients.
Interventions
DEVICEstent, ballooning
DES, BMS, BRS, DEB, and POBA can be used for PCI
Sponsors
Gyeongsang National University Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age \>= 18 years * Significant coronary artery disease * Treated with PCI * Multiple hemostatic or physiologic measurements
Exclusion criteria
* Medically treated cases
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| MACE | up to 10 years | the composite of cardiovascular death, myocardial infarction or stroke |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Revascularization | up to 10 years | target-lesion, target-vessel vs. nontarget-vessel |
| Major bleeding | up to 10 years | BARC type 3-5 |
| Stent thrombosis | up to 10 years | Thrombotic events in & near to stent |
| ISR | up to 10 years | in-stent restenosis |
| Stroke | up to 10 years | Ischemic & hemorrhagic stroke |
| Myocardial infarction | up to 10 years | Fatal & non-fatal myocardial infarction |
| Cardiovascular death | up to 10 years | Mortality related with cardiovascular events |
Other
| Measure | Time frame | Description |
|---|---|---|
| Incidence of MACE according to cardiac contractility | up to 10 years | Echocardiography: LV EF, E/A, TR Vmax, LAVI |
| Incidence of MACE according to physiologic index | up to 10 years | fractional flow reserve (FFR), coronary flow reserve (CFR) and the index of microvascular resistance (IMR) |
| Incidence of MACE according to 1-month bleeding & dyspnea episodes | up to 10 years | Qestionnarres for bleeding, dyspnea, side effects |
| Incidence of MACE according to platelet function | up to 10 years | VerifyNow assay |
| Incidence of MACE according to global hemostasis assay | up to 10 years | thromboelastography (TEG: R, alpha angle, MA and LY30) |
| Incidence of MACE according to hemostatic biomarkers | up to 10 years | hs-CRP, fibrinogen, D-dimer, NT-proBNP, lipid battery |
Countries
South Korea
Contacts
Primary ContactJin Sin Koh, MD, PhD
Outcome results
None listed