Covid19
Conditions
Keywords
Sars-Cov-2, serological test, children, young adults, positive naso-pharyngeal swab, family cluster
Brief summary
Use of rapid serological tests to assess the vulnerability to SARS-CoV-2 infection of subjects aged 4-16 years old and cohabiting with at least one family member who tested positive to SARS-CoV-2
Detailed description
Families with at least one child or young adult aged between 4 and 16 years old and with at least one cohabitant who tested positive to nasopharyngeal swab are contacted by phone. Those who decide to sign an informed consent after reading the study information will be included in the study. It consists of a preliminary telephone interview and a following rapid serological test for all children and young adults with the age included in the range of interest and the cohabitant who tested positive to nasopharingeal swab. The obtained results will be collected and analysed, and the outcomes of the study will be measured.
Interventions
DIAGNOSTIC_TESTSerological test and phone interview
Families are interviewed by telephone to gather information about the family cluster (i.e. age and number of cohabitants, their symptoms and swab results, if performed), the subject who tested positive (i.e.sex, age, course of the disease, symptoms suggestive of COVID-19) and children aged between 4 and 16 y.o. (i.e. sex, age, drug therapy and/or chronic diseases, symptoms suggestive of COVID-19). Children, young adults and the cohabitant who previously tested positive to the swab undergo a serological test for the detection of IgG and IgM antibodies for Sars-Cov-2.
Sponsors
University of Milan
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
4 Years to 99 Years
Healthy volunteers
Yes
Inclusion criteria
1. Children and young adults aged between 4 and 16 years old with at least a Sars-Cov-2 positive cohabitant 2. Adults who previously tested positive to SARS-CoV-2 with at least a cohabitant aged between 4 and 16 y.o. 3. Subjects from the district of Sesto San Giovanni, Lombardy, Italy
Exclusion criteria
1. Children and young adults aged between 4 and 16 years old without at least a cohabitant who previously tested positive to SARS-CoV-2 2. Adults who previously tested positive to SARS-CoV-2 without at least a cohabitant aged between 4 and 16 y.o. 3. Absence of a signed informed consent 4. Subject with symptoms suggestive of COVID-19 in the last 14 days or disease in progress
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Detection of IgG and IgM antibodies for Sars-Cov-2 in children aged between 4 and 16 y.o. cohabiting with at least a subject with a previous diagnosis of COVID-19. | 1-30 days | Assessment of IgG and IgM using serological tests at a single time point. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Detection of IgG and IgM antibodies for Sars-Cov-2 in adults with a previous diagnosis of COVID-19 cohabiting with at least a child aged between 4 and 16 y.o. | 1-30 days | Assessment of IgG and IgM using serological tests at a single time point. |
Countries
Italy
Contacts
Primary ContactGianluca Martino Tartaglia, DDS PhD
Outcome results
None listed