Covid19, SARS (Severe Acute Respiratory Syndrome)
Conditions
Brief summary
Breath gas analysis is the evaluation of exhaled breath. It aims to evaluate the volatile organic compounds (VOCs) in exhaled breath. In this feasibility study it is intended to find specific peaks/pattern in exhaled breath indicating an infection with SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2).
Interventions
Two breathing gas samples will be taken from each study participant using ion mobility spectrometry with an ultrasound-based spirometer. The total sampling time is 1 minute (at least 5-7 breath takes) following an analysis time of 5-12 minutes.
Sponsors
CeGaT GmbH
B. Braun Melsungen AG
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* PCR (= Polymerase Chain Reaction) testing for SARS CoV-2 will be/has been performed in a timely manner of sampling exhaled breath or PCR test for SARS-CoV-2 was performed within 96 hours, but preferably within 48 hours before sampling exhaled breath and PCR test result is already available * Subject must be able to comply with study-specific procedures, e.g.is able to comply with breathing commands
Exclusion criteria
* Previous (history) SARS-CoV-2 infection, independent of the current episode * Participation in a therapeutic study prior to breath analysis which could influence the result of the breath analysis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| SARS-CoV-2 related volatile organic compounds (VOC) | 1 hour after breath gas sampling |
Secondary
| Measure | Time frame |
|---|---|
| To compare the SARS-CoV-2 specific VOC with the clinical symptoms of COVID-19 (Corona Virus Disease 2019) | within 1 hour |
Countries
Germany
Outcome results
None listed