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HIIT for Inflammatory Rheumatic Disease: Man vs Machine

Digitally Assisted High-intensity Interval Training in Inflammatory Rheumatic Disease Patients: Treatment by Man or Machine?

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT04649528
Enrollment
49
Registered
2020-12-02
Start date
2018-01-03
Completion date
2018-03-23
Last updated
2020-12-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Inflammatory Rheumatism

Keywords

VO2max, Cardiovascular health, Quality of life, Endurance exercise

Brief summary

The purpose of this study is to compare two modes of delivering high-intensity interval training (HIIT) in a population with inflammatory rheumatic disease over 10 weeks. One group will recieved HIIT supervised by a healthcare professional, the other group will perform self-monitored HITT with guidance by a smarthpone application.

Detailed description

People with inflammatory rheumatic diseases (IRS) such as rheumatoid arthritis (RA), spondyloarthritis (SpA) and systemic lupus erythematosus (SLE) have been shown to have reduced cardiovascular fitness and quality of life than the general population. Cardiovascular health is the single most important factor of total mortality. It has been shown previously that individuals with IRS tolerate both endurance training, resulting in improvement in function and cardiovascular health while also having a positive effect on disease activity measured through inflammation, pain, joint health and fatigue. In recent years, studies have also been conducted that demonstrate both the safety and effect of aerobic 4x4min high-intensity interval training (HIIT) for patients with IRS. This study will involve an intervention period consisting of 20 HIIT sessions. Participants are randomized into one of two training groups. One group will perform HIIT under the supervision of a healthcare professional. The other group will perform the same HIIT training with identical instructions, however they will be self-monitored with the aid and guidance of a mobilephone application. The purpose of the intervention is to increase maximum oxygen uptake and improve quality of life. The intervention period will consist of 2 weekly sessions lasting approximately 35 minutes performed on non-consecutive days. The endurance training will consist of 4 intervals of 4 minutes duration, separated by a 3-4 minute active break and follows the principle of intensive aerobic interval training. Before and after the training period, identical testing (approximately 30-40 min) will be performed by both intervention groups. The testing will include measurements of work economy and maximal oxygen uptake in an endurance test. Additionally, quality of life questionnaires will be obtained.

Interventions

BEHAVIORALEffective endurance 4x4 training - Supervised

Exercise intervention utilizing 4x4min aerobic high-intensity interval training

DEVICEEffective endurance 4x4 training - APP

Exercise intervention utilizing 4x4min aerobic high-intensity interval training

Sponsors

Molde University College
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Investigator)

Masking description

The exercise physiologist performing the maximal oxygen uptake pre and posttests was blinded with reguards to which intervention group the participants had been assigned.

Intervention model description

Randomized trial

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

\- Inflammatory rheumatic disease

Exclusion criteria

* Inability to complete the testing procedures * Pregancy * Not able to perform exercise intervention * Planed surgeries or other plans during initial exercise intervention period than directly will effect the testing or training. * Access to a smartphone * Less than 80% compliance of planned training sessions

Design outcomes

Primary

MeasureTime frameDescription
Change in physiological measuresAt baseline and after 10 weeks of HIITMaximal oxygen uptake

Secondary

MeasureTime frameDescription
Change in health-related quality of lifeAt baseline and after 10 weeks of HIITQuestionnaire (Norwegian RAND-36), scoring on a 0-100 scale with higher scores identifying better outcomes

Countries

Norway

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 14, 2026